4815-39-8

Upstream product

• 110-91-8 morpholine 
• 833-01-2 2-cyano-3-benzyl-but-2-enoic acid amide 
• 91391-97-8 2-Cyan-3-methyl-4-phenyl-but-2-ensaeure-amid 

Downstream Products

• 176852-91-8 5-methyl-6-phenyl-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one 
• 1213791-70-8 ethyl 3-carbamoyl-4-methyl-5-phenylthiophen-2-ylcarbamate 
• 1213791-71-9 2-(3-ethylureido)-4-methyl-5-phenylthiophene-3-carboxamide 
• 306934-78-1 4-chloro-5-methyl-6-phenylthieno[2,3-d]pyrimidine 
• 1217864-72-6 2,5-dimethyl-6-phenylthieno[2,3-d][1,3]oxazin-4-one 
• 306934-76-9 5-methyl-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Substituted 2-Aminothiopen-derivatives: A potential new class of GluR6-Antagonists

In the course of search for new therapeutic agents against epilepsy new inhibitors for the kainate receptor subtypes GluR5 and GluR6 were synthesized. We were able to synthesize new substituted thieno[2,3-d]pyrimidines 3a,b, 4a,b, 5a,b as well as thiophene-3-carboxamides 2a-d and a multitude of substituted 4-methyl-5-phenylthiophene-3-carboxylic acids. All compounds described herein were tested for their antagonistic effect towards the kainate receptor subtypes GluR5 and GluR6. The highest activity was observed for ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 1c with an IC50 = 0.75 μM at the GluR6 receptor.

Novel Compounds

The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.