17687-63-7

Usage

Uses

Used in Chemical Synthesis:
2-Butanone, 1-chloro-3-methylis used as a synthetic intermediate for the production of various organic compounds, contributing to the development of a range of chemical products.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-Butanone, 1-chloro-3-methylserves as a crucial intermediate in the synthesis of specific medications, playing a key role in drug development and manufacturing processes.
Used in Agrochemical Formulation:
2-Butanone, 1-chloro-3-methylis also utilized as an intermediate in the production of agrochemicals, which are essential for the agricultural sector to ensure crop protection and yield enhancement.
Used as a Solvent:
2-Butanone, 1-chloro-3-methylis employed as a solvent in several industrial processes, facilitating the dissolution of various substances and aiding in chemical reactions.

Upstream product

• 186581-53-3 diazomethane 
• 79-30-1 isobutyryl chloride 
• 563-80-4 3-methyl-butan-2-one 
• 32766-45-3 1,1,1-trichloro-3-methylbutan-2-ol 
• 58866-58-3 (E)-1-chloro-2-(4-chlorobenzenesulfenyl)-3-methyl-butene-1 
• 69561-99-5 3-Methyl-1-trimethylsilanyl-butan-2-one 
• 19967-55-6 1-bromo-3-methyl-2-butanone 
• 7782-50-5 chlorine 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 1068-55-9 isopropylmagnesium chloride 
• 75-18-3 dimethylsulfide 
• 76002-26-1 2-Chlor-2-isopropyloxiran 
• 603-35-0 triphenylphosphine 

Downstream Products

• 17687-64-8 2-(3-methyl-2-oxobutyl)isoindoline-1,3-dione 
• 99595-70-7 1-mercapto-3-methyl-butan-2-one 
• 79932-20-0 2-Amino-4-isopropylthiazole 
• 27784-39-0 3-isopropyl-2,3-dihydro-benzo[4,5]imidazo[2,1-b]thiazol-3-ol 
• 41367-13-9 10-isopropyl-9,10-dihydro-thiazolo[3,2-a]perimidin-10-ol 
• 22940-28-9 2,2-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one 
• 22940-28-9 2,2-dimethyl-3-oxo-8-oxabicyclo[3.2.1]oct-6-ene 
• 10386-03-5 1,2,2-trimethyl-8-oxabicyclo<3.2.1>oct-6-en-3-one 
• 10360-53-9 1,4,4-trimethyl-8-oxabicyclo<3.2.1>oct-6-en-3-one 
• 760-75-8 2-Isopropyl-1,4-pentadiene 
• 7357-93-9 2-ethyl-3-methyl-1-butene 
• 16746-02-4 2-(1-methylethyl)-1-pentene 
• 86409-69-0 3-methyl-2-phenylmethyl-1-butene 
• 74495-41-3 2-amino-5-isopropyl-1,3,4-thiadiazine hydrochloride 

Relevant academic research and scientific papers

Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent "ene"-Reductases

α-Tertiary amines are a common motif in pharmaceutically important molecules but are challenging to prepare using asymmetric catalysis. Here, we demonstrate engineered flavin-dependent ‘ene'-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated charge-transfer complex formed between the substrate and cofactor. These products can be further derivatized to prepare a variety of motifs, highlighting the versatility of ERED photoenzymatic catalysis for organic synthesis.

MAYTANSINOID ANALOGS AS ANTITUMOR AGENTS

Ansamycin analogs, including maytansinoid analogs, and their use in treating cell proliferative diseases and conditions, and in particular, for use as antitumor agents.

S4N4SbCl5 complex: a useful reagent for conversion of sterically less hindred α-bromo ketones to α-chloro ketones

The reactions of sterically less hindered α-bromo alkyl and aryl ketones with tetrasulfur tetranitride antimony pentachloride (S4N4SbCl5) complex in toluene at reflux gave the corresponding α-chloro kerones in good to excellent yields.

Preparation of 1-aminoalkylphosphonic acids and 2-aminoalkylphosphonic acids by reductive amination of oxoalkylphosphonates

By reacting dialkyl 1-oxo- or 2-oxoalkylphosphonates with benzhydrylamine followed by reduction with triacetoxyborohydride and acid hydrolysis gave corresponding aminoalkylphosphonic acids with satisfactory yields. The use of benzylamine, α-methylbenzylamine and tritylamine was unsuccessful in the case of dialkyl 1-oxoalkylphosphonates whereas conversion of 2-oxoalkylphosphonates was also achieved although with lower yields.

Process for the preparation of 3-(2-chloro-2-(4-chloro-phenyl)-vinyl)-2,2-dimethylcyclopropanecarboxylic acid

3-(2-chloro-2-(4-chloro-phenyl)-vinyl)2,2-dimethylcyclopropanecarboxylic acid and its derivatives are obtained by reactive 3-chloro-3(4-chlorophenyl)-propenal with chloromethyl isopropyl ketone in a first step and reacting the resulting 4,4-dimethyl-1,3,6-trichloro-1-(4-chlorophenyl)- hex-1-en-5-one, optionally without isolation, in the presence of aqueous bases or in the presence of alkoxides. The resulting carboxylic acids or carboxylic acid esters can be converted into their derivatives such as, for example, salts, esters, amides or halides by generally known methods.

PRODUCTION OF 1,1,1-TRIHALOGENO-2-ALKANOLS AND SOME OF THEIR PROPERTIES

The reaction of acyclic and carbocyclic carbonyl compounds with haloforms was studied in liquid ammonia and dimethylformamide in the presence of basic catalysts (t-BuOK, KOH).As a result of the reaction 1,1,1-trihalogeno-2-alkanols were obtained.They were used for the synthesis of 1,1,1-trihalogeno-2-methoxyalkanes, 1,1-dibromoalkenes, 1,1-dichloro-2-methoxyalkenes, and alkyl mono- and dichloromethyl ketones.

Preparation of monochloromethyl ketones

A process for the production of a monochloromethyl ketone of the formula STR1 in which R1, R2 and R3 each independently is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkinyl or aryl radical, or R1 and R2 together with the carbon atom to which they are attached form an optionally substituted carbocyclic ring, comprising reacting a 1,1-dichloroalkene of the formula STR2 with a phenolate of the formula STR3 in which R4 each independently is a halogen atom, a nitro group, or an optionally substituted alkyl, alkoxy or aryl radical, n is 0, 1, 2 or 3, and M is one equivalent of an alkali metal ion or alkaline earth metal ion, thereby to obtain a phenyl ether intermediate, and then subjecting the phenyl ether intermediate to an acid hydrolysis. The products are useful as intermediates in the synthesis of fungicides.

Addition of 4-Chlorobenzenesulphenyl Chloride to 3-Methylbut-1-yne, Hex-1-yne, and Phenylacetylene: Isomerisation and Hydrolysis of the Adducts

The addition of (4-ClC6H4SCl, (2), to RCH(*)CH, (1; R=Pri, Bun), gives (E)-4-ClC6H4(R)C(*)C(H)Cl, (E)-(3), and (E)-4-ClC6H4(H)C(*)C(R)Cl, (E)-(4) in a fixed ratio; the addition to (1; R=Ph) gives regiospecifically (E)-(3; R=Ph) in ethyl acetate, but different proportions of (E)-(3) and (E)-(4) (R=Ph), in chloroform, sym-tetrachloroethane, and acetic acid.With an excess of the sulphenyl chloride (2), (E)-(3) and (E)-(4) isomerize to (Z)-(4) (same R).The sulphuric-acid catalysed hydrolysis of (E)-(3; R=Pri, Bun, Ph) gives α-chloroketones RCOCH2Cl(5) (same R).The (E)-(4) isomers do not hydrolyse.