176910-35-3

Usage

Spiro compound

Bicyclic structure with a quaternary carbon atom
The compound has two rings connected by a shared carbon atom, which is bonded to four other carbon atoms.

Synonyms

8-Acetyloxacane
An alternative name for the compound, highlighting its structural features.

Applications

Building block in organic synthesis
The compound is used as a starting material for the synthesis of various organic compounds.

Potential uses

Pharmaceuticals and agrochemicals
The compound has potential applications in the development of drugs and chemicals used in agriculture.

Stability

Relatively stable
The compound is not highly reactive and can be stored and used under normal laboratory conditions.

Physical and chemical properties

Interesting and valuable
The compound has unique properties that make it a useful intermediate in the production of other organic compounds.

Ongoing research

Exploring potential uses in different industries
Scientists are continuously studying the compound to find new applications and improve its synthesis methods.

Upstream product

• 32161-06-1 1-acetyl-4-piperidinone 
• 100-52-7 benzaldehyde 
• 107-21-1 ethylene glycol 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 32161-06-1 1-acetyl-4-piperidinone 
• 3612-18-8 N-ethyl-4-piperidone 
• 497838-42-3 1-(4-dibutylaminopiperidin-1-yl)ethanone 
• 497838-40-1 1-(4-(dimethylamino)piperidin-1-yl)ethanone 

Relevant academic research and scientific papers

Eclipsed Conformation of the Exocyclic N-CH2 Bond in N-Neopentylpiperidines and the Stereodynamic Consequences As Studied by Dynamic NMR Spectroscopy and Molecular Mechanics Calculations

The dynamic stereochemistry of a range of N-neopentylpiperidines 1 with an eclipsed N-CH2-t-Bu bond is compared with that of the corresponding range of N-ethylpiperidines 2 with a gauche N-CH2Me bond. By using dynamic NMR spectroscopy, the relative importance of ring inversion, exocyclic bond rotation, and nitrogen inversion are elucidated and barriers are reported and discussed. Minor populations of the neopentyl-axial-eclipsed conformation are detected directly and identified with the help of molecular mechanics calculations. The corresponding N-alkylpyrrolidines are also reported.

Antinociceptive effects of 1-acyl-4-dialkylaminopiperidine and 1-alkyl-4-dialkylaminopiperidine in mice: Structure-activity relation study of matrine-type alkaloids

We previously reported that (+)-matrine and (+)-allomatrine have antinociceptive properties mediated mainly through the activation of κ-opioid receptors. 1-Acyl-4-dialkylaminopiperidines were synthesized as the simplest derivatives of matrine, and the structure-activity relations were examined by the acetic acid-induced abdominal contraction test. The antinociceptive potencies of 1-alkyl-4-dialkylaminopiperidines were significantly lower than those of the corresponding 1-acyl-4- dialkylaminopiperidines. These findings suggest that the amide group of (+)-matrine is an essential functional group that influences antinociceptive potency.

Ring cleavage reaction of heterocyclic ketones based on crossed aldol condensation

Ring cleavage reaction based on crossed aldol condensation using heterocyclic ketones such as 4-piperidone and nortropinone derivatives with benzaldehyde under acetalization conditions (BF3-Et2O/ethylene glycol) has been achieved.