17692-20-5Relevant academic research and scientific papers
A convenient generation of acetic acid dianion
Parra, Margarita,Sotoca, Enrique,Gil, Salvador
, p. 1386 - 1388 (2007/10/03)
The lithium enediolate of acetic acid can be generated efficiently, as a 0.5 M solution in THF, using lithium amides prepared from n-butyllithium in THF and either diethylamine or 1,3,3-trimethyl-6-azabicyclo-(3.2.1)-octane (AZA). Its reaction with carbon
Synthesis of 3-Hydroxy-3-cyclohexylbutyric Acid Derivatives. 2. Cyclic Analogues of Mevalonic Acid
Carganico, Germano,Cozzi, Paolo,Orsini, Gaetano
, p. 1767 - 1769 (2007/10/02)
The sodium salt of (Z)-3-hydroxy-3-(2-hydroxycyclohexyl)butyric acid (I) and its lactone (II) were prepared through the corresponding tert-butyl ester by hydrogenation, over Rh/Al2O3 catalyst, of the phenyl ring of tert-butyl 3-hydroxy-3-(2-hydroxyphenyl)butyrate (III). (Z)-3-Hydroxy-3-(2-methoxycyclohexyl)butyric acid was prepared similarly. (Z)-4-Methyloctahydro-2H-1-benzopyran-2-one was prepared by hydrogenation, over Rh/Al2O3 catalyst, of 4-methylcoumarine, prepared in turn from III by a one-pot procedure comprising hydrolysis, lactonization, and dehydration.The above compounds inhibit acetate incorporation in cholesterol and fatty acids in rat liver slices at 5 * 10-3 M, but they lack specific inhibitory activity on HMG-CoA reductase.
