17696-89-8Relevant academic research and scientific papers
Preparation method of azodicarbonamide
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Paragraph 0029; 0050-0052; 0057-0059, (2021/12/07)
The preparation method comprises the following steps: Step S1, reacting hydrazine hydrochloride and dimethylbenzoyl chloride to form an intermediate. Step S2: The intermediate is subjected to an even nitridation reaction to give the azodicarboxamide. To the preparation method disclosed by the embodiment of the invention, the adopted raw material is high in safety, less in three wastes formed in production, and the obtained product can be obtained by effectively separating and drying, and pure product TMDA can be obtained without being purified again.
N,N,N',N'-Tetramethylazodicarboxamide (TMAD), A New Versatile Reagent for Mitsunobu Reaction. Its Application to Synthesis of Secondary Amines
Tsunoda, Tetsuto,Otsuka, Junko,Yamamiya, Yoshiko,Ito, Sho
, p. 539 - 542 (2007/10/02)
N,N,N',N'-Tetramethylazodicarboxamide, (TMAD), was found to be more versatile in the Mitsunobu reaction than traditional diethyl azodicarboxylate or recently developed 1,1'-(azodicarbonyl)dipiperidine, when used in combination with tributylphosphine in benzene.The usefulness of the reagent was demonstrated by the highly efficient two-step synthesis of benzylcrotylamine from N-benzyltrifluoroacetamide.
