176972-44-4

Upstream product

• 89-51-0 Homophthalic acid 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 7127-19-7 2-phenyl-1,3-oxazoline 
• 2417-73-4 methyl 2-bromomethylbenzoate 
• 68415-05-4 α-(3,4,5-trimethoxyphenyl)-α-morpholinoacetonitrile 
• 118-41-2 Eudesmic acid 
• 88-67-5 2-Iodobenzoic acid 
• 53560-33-1 3,4,5-trimethoxyphenylacetylene 
• 1046480-78-7 C₂₀H₂₀O₅ 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 118-90-1 ortho-methylbenzoic acid 
• 176972-42-2 2-(3',4',5'-trimethoxybenzoylmethyl)benzoic acid 

Relevant academic research and scientific papers

Rhodium catalyzed carbon-hydrogen bond activation reaction for synthesizing isocoumarin derivative

The invention belongs to the technical field of fine chemicals, and particularly relates to a preparation method of an isocoumarin derivative, and the isocoumarin derivative is a compound shown as a formula (I).

Sulfoxonium Ylides as Carbene Precursors: Rhodium(III)-Catalyzed Sequential C?H Functionalization, Selective Enol Oxygen-Atom Nucleophilic Addition, and Hydrolysis

Herein, we report a protocol for Rh(III)-catalyzed annulation reactions between oxazolines and sulfoxonium ylides via a sequence involving C?H activation, selective enol oxygen-atom nucleophilic addition, and hydrolysis. This practical, operationally simple protocol has a wide substrate range, excellent regioselectivity, and moderate to good yields.

Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins

The biosynthesis of leukotrienes in one of the arachidonic acid pathways and PGE2in the other by 5-LOX and mPGES1 respectively, play pivotal roles in augmenting inflammatory responses. PGE2is known to participate in cancer pathologic

Synthesis of 3-arylisocoumarins by using acyl anion chemistry and synthesis of thunberginol A and cajanolactone A

A new strategy for the synthesis of 3-arylisocoumarins and 8-hydroxy-3-arylisocoumarins was investigated by using acyl anion chemistry for the initial C-C bond formation. The obtained keto esters and keto lactones as intermediates underwent based-promoted intramolecular cyclization to afford 3-arylisocoumarins in good yields. The developed methodology was applied for the synthesis of the important natural products thunberginol A and cajanolactone A.

3-Substituted isocoumarins as thymidine phosphorylase inhibitors

3-Substituted isocoumarins 1-19 were synthesized and evaluated for their thymidine phosphorylase inhibitory activity. Eight (8) compounds exhibited a varying degree of inhibitory activity towards thymidine phosphorylase from E. coli with IC50 values between 61- 402 μM. The activities were compared with the standard 7-deazaxanthine (IC50 = 39.28 ± 0.76 μM).

Copper-catalyzed preparation of γ-alkylidenebutenolides and isocoumarins under mild palladium-free conditions

A general and efficient copper(I)-catalyzed cross-coupling and heterocyclization reaction of terminal alkynes and β-iodo-α,β- unsaturated acid derivatives has been developed under very mild conditions. This method provides easy access from good to excellent yields of a variety of 5-ylidenebutenolides and 3-substituted isocoumarins with excellent regio- and stereoselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.

Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields. Georg Thieme Verlag Stuttgart.

Synthesis of 3-aryl- and 3-aryl-3,4-dihydroisocoumarins

The condensation of homophthalic acid 6 with the appropriate acid chlorides 7a-c yield the respective isocoumarins 8a-c, which are converted to keto-acids 9a-c by alkaline hydrolysis. The 3,4-dihydroisocoumarins 12a-c are obtained by reduction of the keto

The preparation of 2-(2-oxo-2-phenylethyl)benzoic acids from dilithiated ortho-toluic acid

Ortho-Toluic acid was dimetalated with excess lithium diisopropylamide, and the resulting intermediate was condensed with a variety of aromatic esters to afford new substituted 2-(2-oxo-2-phenylethyl)benzoic acids (ortho-phenacylbenzoic acids).