17698-09-8

Usage

Class of organic compounds

Benzoic acids and derivatives 2-(hydroxycarbamoyl)benzoic acid belongs to a group of compounds that are derived from benzoic acid and have similar chemical properties.

Derivation

Combination of 2-amino-1,3-propanediol and 2-hydroxybenzoic acid The compound is formed by reacting these two starting materials, resulting in the formation of the desired product.

Physical appearance

White crystalline solid 2-(hydroxycarbamoyl)benzoic acid has a solid, crystalline structure with a white color.

Solubility

Sparingly soluble in water The compound does not dissolve easily in water, which may affect its behavior and applications in various processes.

Common use

Production of pharmaceuticals 2-(hydroxycarbamoyl)benzoic acid is often used in the synthesis of pharmaceutical compounds, particularly as an intermediate in the production of antineoplastic agents (anticancer drugs).

Specific application

Chelating agent in analytical chemistry The compound can bind to metal ions, making it useful as a chelating agent in analytical chemistry for tasks such as complexation, purification, and analysis of metal ions.

Chemical structure and properties

Versatile compound with various potential applications The unique structure and properties of 2-(hydroxycarbamoyl)benzoic acid make it a valuable compound for further research and development in different fields.

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 64-17-5 ethanol 
• 17720-64-8 N-acetoxyphthalimide 
• 7732-18-5 water 
• 85-44-9 phthalic anhydride 
• 2306-33-4 monoethyl phthalate 
• 77-36-1 chlorthalidon 
• 4376-18-5 Monomethyl phthalate 

Downstream Products

• 524-38-9 N-hydroxyphthalimide 
• 118-92-3 anthranilic acid 
• 100961-82-8 N-benzoyloxy-phthalamic acid 
• 85-44-9 phthalic anhydride 
• 7803-49-8 hydroxylamine 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 339106-00-2 2-(2,4-dichlorobenzyloxy)isoindole-1,3-dione 
• 16653-19-3 N-(benzyloxy)phthalimide 
• 34837-67-7 2-(phenylsulfonamido)benzoic acid 
• 17720-64-8 N-acetoxyphthalimide 

Relevant academic research and scientific papers

Hydroxamic acid rearrangement method for O-amino aromatic acid

The invention relates to the field of organic functional new material chemicals, and discloses a novel process technology for preparation of a hydroxamic acid precursor body weight discharge method of a plurality of o-amino aromatic acids in the first time. These substances are well known dyes and pigment and pharmaceutical pesticide-related fields and have a wide range of critical fine chemicals.

Synthesis, Crystal Structure, Herbicidal Activity, and SAR Study of Novel N-(Arylmethoxy)-2-chloronicotinamides Derived from Nicotinic Acid

Nicotinic acid, also known as niacin, is a natural product, which is widely found in plants and animals. To discover novel natural-product-based herbicides, a series of N-(arylmethoxy)-2-chloronicotinamides were designed and synthesized. Some of the new N-(arylmethoxy)-2-chloronicotinamides exhibited excellent herbicidal activity against Agrostis stolonifera (bentgrass) at 100 μM. Compound 5f (2-chloro-N-((3,4-dichlorobenzyl)oxy)nicotinamide) possessed excellent herbicidal activity against Lemna paucicostata (duckweed), with an IC50 value of 7.8 μM, whereas the commercial herbicides clomazone and propanil had values of 125 and 2 μM, respectively. The structure-activity relationships reported in this paper could be used for the development of new herbicides against monocotyledonous weeds.

N-(benzyloxy)-2-chloronicotinamide compound as well as preparation method and application thereof

The invention belongs to the technical field of chemical synthesis and medicine application, and particularly relates to preparation and application of an N-(benzyloxy)-2-chloronicotinamide compound. The preparation method comprises the following steps: reacting phthalic anhydride with hydroxylamine, then reacting with triethylamine for acidification to prepare N-hydroxyphthalimide, then carrying out substitution and hydrazinolysis, and finally reacting with dichloronicotinoyl chloride to prepare the N-(benzyloxy)-2-chloronicotinamide compound. The preparation method disclosed by the invention is simple and convenient to operate, the structure of the obtained product is confirmed by a nuclear magnetic hydrogen spectrum, herbicidal activity tests are carried out on the obtained 15 target products, and results show that all target compounds have an obvious inhibition effect on the seeds of the Agrostis matsumurae under the concentration of 1mM, and the inhibition effect reaches 100%; and along with the decrease of the concentration, even if the concentration reaches 100 [mu] M, the target compound can still show good herbicidal activity.

Preparation method of hydroxamic acid (by machine translation)

The preparation method comprises the following steps: carrying out a reaction on acid anhydride and hydroxylamine under alkali catalysis; acidification is carried out after reaction is completed; wherein, the acid anhydride is C4 - C12-alkane fatty acid anhydride or an acid anhydride of aromatic acid. To the preparation method provided by the invention, the hydroximation reaction can be realized without heating, the reaction condition is mild, the side reaction is small, and the obtained product is high in purity. The method has the advantages that the synthesis conversion rate is high, the raw material consumption proportion is reduced, the synthesis cost is greatly reduced, the acid needed for the subsequent acidification process is reduced greatly, the generated waste residue sodium chloride is reduced, and the wastewater discharge amount is reduced by about 50% or more. (by machine translation)

PRODUCTION OF CYCLIC IMIDES SUITABLE FOR OXIDATION CATALYSIS

Disclosed are novel processes for the production of cyclic imide compounds such as N-hydroxyphthalimide (NHPI). The processes may be particularly well-suited for commercial-scale production of cyclic imides such as NHPI. Such cyclic imide compounds are suitable for use as oxidation catalysts, and specifically may be used to oxidize cyclohexylbenzene to cyclohexyl-1-phenyl-1-hydroperoxide. Such an oxidation may be particularly useful in a process for the production of phenol and/or cyclohexanone from benzene via a process comprising hydroalkylation of benzene to cyclohexylbenzene, oxidation of the cyclohexylbenzene to cyclohexyl-1-phenyl-1-hydroperoxide, and cleavage of the cyclohexyl-1-phenyl-1-hydroperoxide to phenol and cyclohexanone. The cyclic imide production process may advantageously include water washing and reactant recovery steps to maximize purity and yield.

Study of the photochemical and in vitro phototoxicity of chlortalidone [2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzene sulfonamide]

The photodegradation process of the phototoxic diuretic drag chlorthalidone was studied. The products of its photolysis under UV-B were isolated and identified. Chlorthalidone was found to be active when examined by photohemolysis on human erythrocytes, but not in the presence of the isolated photoproducts. Inhibition of the photohemolysis process induced by chlorthalidone on addition of reduced glutathione (GSH) or ascorbic acid suggests the involvement of radicals species. The inhibition with 1,4- diazabycyclo [2.2.2] octane (DABCO), sodium azide (NAN3) sowie 2,5- dimethylfuran proof the participation of singlet oxygen (1O2) in this process.