17700-54-8

Usage

Uses

Used in Pharmacological Activity:
2,6-DICHLOROACETANILIDE is used as a compound for pharmacological activity, specifically in the dynamic method of determination of octanol-water partition coefficient of 2,4-dihydroxythiobenzanilides. This application is crucial for understanding the compound's interaction with biological systems and its potential as a therapeutic agent.
Used in Biological Studies:
In biological studies, 2,6-DICHLOROACETANILIDE serves as a valuable tool for investigating the properties and behavior of various biological systems. Its use in QSAR (Quantitative Structure-Activity Relationship) studies helps researchers predict the biological activity of related compounds, which can be instrumental in drug discovery and development.
Used in QSAR Studies:
2,6-DICHLOROACETANILIDE is used as a reference compound in QSAR studies, which aim to establish a quantitative relationship between the chemical structure of a compound and its biological activity. This information is vital for designing new drugs with improved efficacy and reduced side effects.

InChI:InChI=1/C8H7Cl2NO/c1-5(12)11-8-6(9)3-2-4-7(8)10/h2-4H,1H3,(H,11,12)

Upstream product

• 75-36-5 acetyl chloride 
• 608-31-1 2,6-Dichloroaniline 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 103-88-8 4-bromoacetanilide 
• 601-88-7 2,6-dichloronitrobenzene 
• 10468-16-3 2-chloro-N-hydroxybenzenamine 
• 82344-32-9 N-(o-chlorophenyl)-acetohydroxamic acid 

Downstream Products

• 98141-54-9 4-amino-3,5-dichloro-phenylsulphonic acid chloride 
• 99310-46-0 acetic acid-(2,6,N-trichloro-anilide) 
• 67624-90-2 N-(2,6-dichloro-phenyl)-2-morpholin-4-yl-acetamide 
• 137090-08-5 N-(2,6-Dichloro-phenyl)-N-methyl-acetamide 
• 13277-07-1 3.5-Dichlorsulfanilyl-hydrazid 
• 13953-09-8 4-bromo-2,6-dichloroacetanilide 
• 153466-62-7 N-(2,6-dichlorophenyl)-<2H5>-phenylamine 
• 153466-64-9 1-(2,6-dichlorophenyl)-2-<2H4>-indoline 
• 153466-65-0 o-<(2,6-dichlorophenyl)amino>-<2H4-phenyl>-acetic acid 
• 153466-63-8 2-chloro-N-(2,6-dichlorophenyl)-N-<2H5-phenyl>-acetamide 
• 15178-58-2 p-amino-3,5-dichlorobenzenethiol 
• 23153-07-3 2,6-dichloro-4-(methylthio)aniline 
• 108130-06-9 acetic acid-(2,6-dichloro-4-methylsulfanyl-anilide) 
• 109047-10-1 chloro-acetic acid-(2,6-dichloro-4-methylsulfanyl-anilide) 

Relevant academic research and scientific papers

Facile synthesis of 2′-acetamido-m-terphenyls via Suzuki coupling

Reaction of 2′-amido-m-terphenyl with NaOH and Br2 gave substituted phenanthridinone instead of undergoing rearrangement to give acetamido-m-terphenyl. Thermolysis of 2′-azido-m-terphenyl also gave the phenanthridinone in good yield. The synthesis of 2′-m-terphenyls was accomplished via Suzuki coupling.

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

SULFONAMIDES AND THEIR USE AS HERBICIDES

The present invention relates to compounds of Formula (I), wherein R1 and R2 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.

AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND DERIVATIVES THEREOF

The present disclosure relates to amine-substituted heterocyclic compounds and derivatives thereof. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) by administering an amine-substituted heterocyclic heterocyclic compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate (supported on silica gel) as a new and efficient catalyst for acylation of alcohols, phenols and amines under solvent-free conditions

In the present work, L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate, supported on silica gel was prepared and characterized by Mass spectroscopy, 1H NMR, 13CNMR, FT IR and elemental analysis (CHN) methods. This heterogenized catalyst can be used as an efficient catalyst for the acylation of alcohols, phenols, and amines with acetic anhydride under mild and solvent-free conditions. Simple work-up, stability of the catalyst, nontoxicity and good to high yields are the advantages of this work.

1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists

A series of 1-(3-aryloxyaryl)benzimidazoles incorporating a sulfone substituent (6) was prepared. High affinity LXR ligands were identified (LXRβ binding IC50 values 10 nM), some with excellent agonist potency and efficacy in a functional assay of LXR activity measuring ABCA1 mRNA increases in human macrophage THP1 cells. The compounds were typically stable in liver microsome preparations and had good oral exposure in mice.

Photochemistry of 2,6-Dichlorodiphenylamine and 1-Chlorocarbazole, the Photoactive Chromophores of Diclofenac, Meclofenamic Acid and Their Major Photoproducts

Diclofenac and meclofenamic acid are two structurally related nonsteroidal anti-inflammatory drugs with some photosensitizing potential. Their photochemistry involves cyclization to monohalogenated carbazoles. In principle, photocyclization could occur by photodehalogenation, followed by intramolecular radical addition, or by 6π electrocyclization and subsequent dehydrohalogenation of the intermediate dihydrocarbazoles. Previously, it has been assumed that the reaction follows the first pathway and that the key species associated with phototoxicity are the resulting aryl radicals. In the present work, we have performed photophysical and photochemical studies on 2,6-dichlorodiphenylamine (1a). This is a suitable model compound because since it contains the active chromophore present in diclofenac and meclofenamic acid, and its photoreactivity should be relevant to the understanding of the photobiological properties of both drugs. Our results clearly show that the first photochemical reaction is a very rapid 6π-electrocyclization, and hence no radicals are formed at this stage. Instead, cleavage of the carbon-halogen bond occurs in the 1-chlorocarbazole photoproduct 2a. The reduced lifetime of the 2a triplet (as compared with the unsubstituted carbazole) and the observed reaction quenching by oxygen are in agreement with the reaction occurring from the excited triplet state. Overall, the above results suggest that the potential phototoxicity of diclofenac and meclofenamic acid is due to a photobiologically active photoproduct that is able to generate radicals upon photolysis, rather than to the parent drug.

Synthesis of deuterium-labelled diclofenac sodium

Diclofenac sodium labelled with deuterium in the phenylacetic ring was prepared from [2H5]-bromobenzene in a six-step reaction. It was found to be suitable for use in pharmacokinetic and bioavailability studies in man.

Effect of substituents in the formation of diacetanilides

A number of diacetanilides, including some which have not been reported so far, have been synthesized from the corresponding monoacetyl derivatives and characterized by spectral and elemental analyses.A tlc/fid method for the quantitative estimation of the relative amounts of mono- and diacetyl derivatives has been standardized.Linear correlation of the extent of diacetylation with Hammett ?-values of substituents and basicity constants of monoacetyl derivatives has been established.A plausible mechanism for the diacetylation reaction based on experimental observations has been suggested.An explanation for the anomalous behaviour of acetanilides containing electron-withdrawing substituents in the ortho-position has been put forth.