17701-24-5Relevant academic research and scientific papers
New organotin(IV) ascorbates: Synthesis, spectral characterization, biological and potentiometric studies
Nath, Mala,Jairath, Ruchi,Eng, George,Song, Xueqing,Kumar, Ashok
, p. 77 - 86 (2005)
New organotin(IV) ascorbates of the general formulae R3Sn(HAsc) (where R = Me, n-Pr, n-Bu and Ph) and R2Sn(Asc) (where R = n-Bu and Ph) have been synthesized by the reaction of RnSnCl4-n (where n = 2 or 3) with monosodium-L-ascorbate. The bonding and coordination behaviour in these complexes are discussed on the basis of UV-Vis, IR, Far-IR, 1H and 13C NMR, and 119Sn Moessbauer spectroscopic studies. L-Ascorbic acid acts as a monoanionic bidentate ligand in R3Sn(HAsc) coordinating through O(1) and O(3). The Moessbauer studies together with IR and NMR studies suggest that for these polymeric derivatives, the polyhedron is trigonal bipyramidal around tin with three organic groups in the equatorial positions. In R2Sn(Asc), L-ascorbic acid acts as dianionic tetradentate ligand and a polymeric structure with octahedral geometry around tin with trans organic groups has been tentatively proposed. The complexes have been assayed for their anti-inflammatory and cardiovascular activity. Ph2Sn(Asc) has been found to show the highest activity among the studied complexes. It is suggested on the basis of potentiometric studies of Me2Sn(IV) and Me3Sn(IV) systems with L-ascorbic acid that under physiological conditions (pH = 7.0) Me 2Sn(HAsc)(OH) (～60%), Me2Sn(OH)2 (～40%) and Me3Sn(HAsc) (～60%), Me3Sn(OH) (～40%), respectively, are existing, which may be responsible for their biological activities.
Interaction of antitumor drug Sn(CH3)2Cl2 with DNA and RNA
Nafisi, Shohreh,Sobhanmanesh, Amir,Esm-Hosseini, Majid,Alimoghaddam, Kamran,Tajmir-Riahi, Heidar Ali
, p. 22 - 27 (2005)
Sn(CH3)2Cl2 exerts its antitumor activity in a specific way. Unlike anticancer cis-Pt(NH3)2Cl 2 drug which binds strongly to the nitrogen atoms of DNA bases, Sn(CH3)2Cl2 shows no major affinity towards base binding. Thus, the mechanism of action by which tinorganometallic compounds exert antitumor activity would be different from that of the cisplatin drug. The aim of this study was to examine the binding of Sn(CH3) 2Cl2 with calf thymus DNA and yeast RNA in aqueous solutions at pH 7.1-6.6 with constant concentrations of DNA and RNA and various molar ratios of Sn(CH3)2Cl2/DNA (phosphate) and Sn(CH3)2Cl2/RNA of 1/40, 1/20, 1/10, 1/5. Fourier transform infrared (FTIR) and UV-visible difference spectroscopic methods were used to determine the Sn(CH3)2Cl2 binding mode, binding constant, sequence selectivity and structural variations of Sn(CH3)2Cl2/DNA and Sn(CH3) 2Cl2/RNA complexes in aqueous solution. Sn(CH 3)2Cl2 hydrolyzes in water to give Sn(CH 3)2(OH)2 and [Sn(CH3) 2(OH)(H2O)n]+ species. Spectroscopic evidence showed that interaction occurred mainly through (CH3) 2Sn(IV) hydroxide and polynucleotide backbone phosphate group with overall binding constant of K(Sn(CH3)2Cl 2-DNA)=1.47×105 M-1 and K(Sn(CH 3)2Cl2-RNA)=7.33×105 M -1. Sn(CH3)2Cl2 induced no biopolymer conformational changes with DNA remaining in the B-family structure and RNA in A-conformation upon drug complexation.
