177017-68-4

Basic information

• Product Name: (R)-(+)-6-METHOXY 2-AMINOTETRALIN
• Synonyms: (R)-(+)-6-METHOXY 2-AMINOTETRALIN;(R)-6-METHOXY-2-AMINOTETRALIN;(R)-2-Amino-6-methoxy-1,2,3,4-tetrahydronaphthalene
• CAS NO: 177017-68-4
• Molecular Formula: C11H15NO
• Molecular Weight: 177.24
• Mol File: 177017-68-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 299.6 °C at 760 mmHg
• Flash Point: 139.7 °C
• Appearance: /
• Density: 1.056 g/cm³
• Vapor Pressure: 0.00118mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: (R)-(+)-6-METHOXY 2-AMINOTETRALIN(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-6-METHOXY 2-AMINOTETRALIN(177017-68-4)
• EPA Substance Registry System: (R)-(+)-6-METHOXY 2-AMINOTETRALIN(177017-68-4)

Safety Data

• Hazardous Substances Data: 177017-68-4(Hazardous Substances Data)

Usage

General Description

(R)-(+)-6-Methoxy 2-aminotetralin is a chemical compound that belongs to the class of aminotetralins. It is a chiral compound with a specific spatial arrangement of its atoms, resulting in two enantiomers, (R)-(+)- and (S)-(-)-. The (R)-(+)-enantiomer is known for its potential pharmacological effects, including its ability to act as a potent dopamine agonist. (R)-(+)-6-METHOXY 2-AMINOTETRALIN has been studied for its potential therapeutic applications in the treatment of Parkinson's disease and other neurological disorders. Additionally, it has also been investigated for its role in modulating neurotransmitter systems in the brain, potentially leading to therapeutic benefits in the field of neuropsychiatric disorders. Overall, (R)-(+)-6-methoxy 2-aminotetralin is a chemical compound with promising pharmacological properties that could make it a valuable tool in medical research and drug development.

InChI:InChI=1/C11H15NO/c1-13-11-5-3-8-6-10(12)4-2-9(8)7-11/h3,5,7,10H,2,4,6,12H2,1H3/t10-/m1/s1

Upstream product

• 623-26-7 terephthalonitrile 
• 52178-91-3 7-methoxy-1,2-dihydronaphthalene 
• 2472-22-2 6-methoxy-2-tetralone 
• 2398-37-0 3-methoxyphenyl bromide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 281199-10-8 2-((R)-6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-isoindole-1,3-dione 
• 1447-87-6 2-hydroxy-6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 5486-55-5 2,6-dimethoxylnaphthalene 
• 581-43-1 2.6-dihydroxynaphthalene 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 744174-28-5 N-benzyl-6-methoxytetralin-2-amine 
• 81861-29-2 6-Methoxy-3,4-dihydro-1H-naphthalen-2-one O-methyl-oxime 
• 37563-97-6 6-methoxy-3,4-dihydro-[1,2]-naphthoquinone-2-oxime 

Downstream Products

• 4003-88-7 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride 
• 70312-01-5 2-amino-1,2,3,4-tetrahydro-6-hydroxynaphthalene 

Relevant articles and documents

Artificial multi-enzyme networks for the asymmetric amination of sec-alcohols

Various artificial network designs that involve biocatalysts were tested for the asymmetric amination of sec-alcohols to the corresponding α-chiral primary amines. The artificial systems tested involved three to five redox enzymes and were exemplary of a range of different sec-alcohol substrates. Alcohols were oxidised to the corresponding ketone by an alcohol dehydrogenase. The ketones were subsequently aminated by employing a ω-transaminase. Of special interest were redox-neutral designs in which the hydride abstracted in the oxidation step was reused in the amination step of the cascade. Under optimised conditions up to 91 % conversion of an alcohol to the amine was achieved. Trickle-down effect: The asymmetric amination of sec-alcohols to the corresponding α-chiral primary amines was performed with a biocatalytic cascade whereby the various steps were interconnected through the cofactors/cosubstrates. In a redox-neutral cascade and under optimised conditions, up to 91 % conversion of an alcohol to the amine was achieved. Copyright

INDOLE AHR INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

Asymmetric amination of tetralone and chromanone derivatives employing ω-transaminases

Various (S)-selective and (R)-selective ω-transaminases were investigated for the amination of 1- and 2-tetralone and derivatives as well as of 3- and 4-chromanone. All ketones tested were aminated to give the corresponding enantiopure amines (ee > 99%) employing at least one of the enzymes investigated. In most of the cases the (S)- as well as the (R)-enantiomer was obtained in optically pure form. The amination of 3-chromanone was performed on a 100 mg scale leading to optically pure (R)-3-aminochromane (ee > 99%) with complete conversion and 78% isolated yield.