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177017-69-5

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177017-69-5 Usage

General Description

(S)-(-)-6-Methoxy 2-aminotetralin is a chemical compound that belongs to the class of amines. It is a chiral compound, meaning it has a non-superimposable mirror image. (S)-(-)-6-METHOXY 2-AMINOTETRALIN has a molecular structure consisting of a six-membered ring with a methoxy group (CH3O) and an amino group (-NH2) attached to it. It can be used as a building block in the synthesis of various drugs and pharmaceuticals, including potential antidepressants and analgesics. Additionally, it has shown activity as a dopamine receptor agonist, making it a potential candidate for the development of treatments for neurological disorders. Overall, (S)-(-)-6-methoxy 2-aminotetralin has potential applications in both the pharmaceutical and research industries.

Check Digit Verification of cas no

The CAS Registry Mumber 177017-69-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,0,1 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 177017-69:
(8*1)+(7*7)+(6*7)+(5*0)+(4*1)+(3*7)+(2*6)+(1*9)=145
145 % 10 = 5
So 177017-69-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO/c1-13-11-5-3-8-6-10(12)4-2-9(8)7-11/h3,5,7,10H,2,4,6,12H2,1H3/t10-/m0/s1

177017-69-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-6-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:177017-69-5 SDS

177017-69-5Relevant articles and documents

INDOLE AHR INHIBITORS AND USES THEREOF

-

, (2018/11/22)

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

Asymmetric amination of tetralone and chromanone derivatives employing ω-transaminases

Pressnitz, Desiree,Fuchs, Christine S.,Sattler, Johann H.,Knaus, Tanja,Macheroux, Peter,Mutti, Francesco G.,Kroutil, Wolfgang

, p. 555 - 559 (2013/06/05)

Various (S)-selective and (R)-selective ω-transaminases were investigated for the amination of 1- and 2-tetralone and derivatives as well as of 3- and 4-chromanone. All ketones tested were aminated to give the corresponding enantiopure amines (ee > 99%) employing at least one of the enzymes investigated. In most of the cases the (S)- as well as the (R)-enantiomer was obtained in optically pure form. The amination of 3-chromanone was performed on a 100 mg scale leading to optically pure (R)-3-aminochromane (ee > 99%) with complete conversion and 78% isolated yield.

Artificial multi-enzyme networks for the asymmetric amination of sec-alcohols

Tauber, Katharina,Fuchs, Michael,Sattler, Johann H.,Pitzer, Julia,Pressnitz, Desiree,Koszelewski, Dominik,Faber, Kurt,Pfeffer, Jan,Haas, Thomas,Kroutil, Wolfgang

, p. 4030 - 4035 (2013/04/10)

Various artificial network designs that involve biocatalysts were tested for the asymmetric amination of sec-alcohols to the corresponding α-chiral primary amines. The artificial systems tested involved three to five redox enzymes and were exemplary of a range of different sec-alcohol substrates. Alcohols were oxidised to the corresponding ketone by an alcohol dehydrogenase. The ketones were subsequently aminated by employing a ω-transaminase. Of special interest were redox-neutral designs in which the hydride abstracted in the oxidation step was reused in the amination step of the cascade. Under optimised conditions up to 91 % conversion of an alcohol to the amine was achieved. Trickle-down effect: The asymmetric amination of sec-alcohols to the corresponding α-chiral primary amines was performed with a biocatalytic cascade whereby the various steps were interconnected through the cofactors/cosubstrates. In a redox-neutral cascade and under optimised conditions, up to 91 % conversion of an alcohol to the amine was achieved. Copyright

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