31166-29-7

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Dichlorothiophene-2-carboxylic acid is used as a key intermediate in the synthesis of compounds that serve as therapeutic BACE1 and BACE2 inhibitors. These inhibitors are crucial for the treatment of Alzheimer's disease, as they help in reducing the formation of amyloid-beta peptides, which are associated with the development of the disease. Additionally, BACE1 inhibitors have potential applications in the treatment of type 2 diabetes and other metabolic disorders, making 4,5-Dichlorothiophene-2-carboxylic acid an essential component in the development of novel therapeutic agents for these conditions.

InChI:InChI=1/C5H2Cl2O2S/c6-2-1-3(5(8)9)10-4(2)7/h1H,(H,8,9)

Upstream product

• 67482-49-9 4,5-dichlor-2-thiophenecarboxaldehyde 
• 6324-10-3 4,5-Dibromo-thiophene-2-carboxylic acid 
• 57681-59-1 1-(4,5-Dichlor-2-thienyl)-ethanon 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 527-72-0 2-thiophenylcarboxylic acid 
• 88-15-3 2-Acetylthiophene 
• 122065-05-8 2,3-dichloro-5-chloromethyl-thiophene 
• 130562-97-9 4,5-dichloro-2-thiophenecarboxylic acid ethyl ester 
• 17249-79-5 2,3-Dichlorothiophene 
• 124-38-9 carbon dioxide 
• 89281-29-8 2,3-dichlorothiophene-5-carboxylic acid methyl ester 

Downstream Products

• 17249-79-5 2,3-Dichlorothiophene 
• 89281-29-8 2,3-dichlorothiophene-5-carboxylic acid methyl ester 
• 1770812-37-7 (S)-4,5-dichloro-N-[[2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl]methyl]-2-thiophenecarboxamide 

Relevant academic research and scientific papers

An efficient and facile process for synthesis of 4,5-dichlorothiophene-2-carboxylic acid using N-chlorosuccinimide

4,5-Dichlorothiophene-2-carboxylic acid was obtained from the starting material thiophene-2-carboxylic acid via esterification, chlorination and hydrolysis. The chlorination reaction was achieved using N.chlorosuccinimide as the chlorinating agent with high selectivity and yield. The advantages of this synthesis route were mild reaction conditions, simplified operational procedure and the raw materials were easy to obtain. It could be applied to industrial production.

Phosphorylamides, their preparation and use

A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.

Herbicidal Thienylureas, I

Syntheses of the title substances as potential herbicides are described by a modified Curtius degradation of corresponding thiophene carboxylic acids, obtained in turn by haloform reaction of appropriate acetyl thiophenes.Regioselective substitution reactions of thiophenes were key steps for the construction of desired substitution patterns.Structure-activity considerations show that especially the 3-thienyl ureas 36 and 38 exhibit significant herbicidal activity comparable with commercial products. - Keywords: Curtius degradation; Herbicides; Thiophenes; Ureas; Urethanes