177202-62-9

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, Methyl ester
• Synonyms: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, Methyl ester;Methyl 1,2,3,4-tetrahydroquinoline-3-carboxylate
• CAS NO: 177202-62-9
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• Mol File: 177202-62-9.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, Methyl ester(177202-62-9)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, Methyl ester(177202-62-9)

Safety Data

• Hazardous Substances Data: 177202-62-9(Hazardous Substances Data)

Upstream product

• 177198-41-3 N-benzyloxycarbonyl-3(R,S)-methoxycarbonyl-1,2,3,4-tetrahydroquinoline 
• 6480-68-8 quinoline-3-carboxylic acid 
• 64-19-7 acetic acid 
• 53951-84-1 methyl quinolone-3-carboxylate 

Downstream Products

• 1574000-25-1 2-methyl-5-(3-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)-3,4-dihydroquinolin-1(2H)-yl)benzoic acid hydrochloride 

Relevant articles and documents

Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity

With approximately 37 million people living with HIV worldwide and an estimated 2 million new infections reported each year, the need to derive novel strategies aimed at eradicating HIV-1 infection remains a critical worldwide challenge. One potential strategy would involve eliminating infected cells via antibody-dependent cellular cytotoxicity (ADCC). HIV-1 has evolved sophisticated mechanisms to conceal epitopes located in its envelope glycoprotein (Env) that are recognized by ADCC-mediating antibodies present in sera from HIV-1 infected individuals. Our aim is to circumvent this evasion via the development of small molecules that expose relevant anti-Env epitopes and sensitize HIV-1 infected cells to ADCC. Rapid elaboration of an initial screening hit using parallel synthesis and structure-based optimization has led to the development of potent small molecules that elicit this humoral response. Efforts to increase the ADCC activity of this class of small molecules with the aim of increasing their therapeutic potential was based on our recent cocrystal structures with gp120 core.

SMALL MOLECULES THAT SENSITIZE HIV-1 INFECTED CELLS TO ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY

Compounds and methods of treating HIV-1 in a human infected with HIV-1 or preventing HIV-1 infection in a human susceptible to infection with HIV-1 are provided. The compounds are of formula (I), (II), and (IA), wherein R1-R7, X, X', Y, Y', Z, and n are defined herein, and the methods comprises administering therapeutically effective amounts of these compounds to the human.

SMALL MOLECULE INHIBITORS OF THE MCL-1 ONCOPROTEIN AND USES THEREOF

Compounds that inhibit Myeloid Cell Leukemia-1 (Mcl-1) oncoprotein, and methods of using the same, are provided for treating disease.