177211-81-3

Upstream product

• 67-56-1 methanol 
• 98-88-4 benzoyl chloride 
• 143812-76-4 8-Trifluoromethyl-tetrazolo[1,5-a]pyridine 
• 94238-64-9 6-trifluoromethyl-2-azidopyridine 
• 177211-80-2 2-methoxy-4-trifluoromethyl-1H-1,3-diazepine 

Relevant academic research and scientific papers

1H-1,3-Diazepines, 5H-1,3-diazepines, 1,3-diazepinones, and 2,4-diazabicyclo[3.2.0]heptenes

Tetrazolo[1,5-a]pyridines/2-azidopyridines 1 undergo photochemical nitrogen elimination and ring expansion to 1,3-diazacyclohepta-1,2,4,6-tetraenes 3, which react with alcohols to afford 2-alkoxy-1H/-13-diazepines 4 (5), with secondary amines to 2-dialkyl

Synthesis of 1H- and 5H-1,3-diazepines from azido- and tetrazolo-pyridines

Stable 1H-1,3-diazepines 7-9, 10, 13, 14, 17 and 19 are obtained, often in high yields, by photolysis of trifluoromethyl-substituted azido- or tetrazolo-pyridines in the presence of alcohols or amines; in some cases, 5H-1,3-diazepines are also formed (11, 21 and 23).