177274-66-7

Usage

Derivative of indole

A heterocyclic aromatic organic compound that serves as the base structure for 1-phenylsulfonyl-3-bromo-2-methylindole.

Sulfonyl group

A functional group containing a sulfur atom double-bonded to an oxygen atom and single-bonded to another oxygen atom (-SO2) attached to the 3rd carbon atom of the indole ring.

Bromine atom

A halogen atom (bromine) attached to the 2nd carbon atom of the indole ring, which can be involved in various chemical reactions and substitutions.

Organic synthesis reactions

The compound is used as a reactant in various organic synthesis processes, allowing for the formation of new chemical bonds and the creation of more complex molecules.

Pharmaceutical research

The compound serves as a valuable building block in the development of new pharmaceuticals, potentially leading to the discovery of novel drugs and therapies.

Building block for other organic compounds

Due to its unique structure and functional groups, 1-phenylsulfonyl-3-bromo-2-methylindole can be used as a starting material for the synthesis of other complex organic compounds, making it a versatile intermediate in chemical research.

Upstream product

• 1496-78-2 3-bromo-2-methyl-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 95-20-5 2-methyl-1H-indole 
• 85678-41-7 N-benzenesulphonyl-2-methyl-3-thiophenoxyindole 

Downstream Products

• 856111-06-3 1-benzenesulfonyl-3-bromo-2-phenylsulfanylmethyl-1H-indole 
• 697285-16-8 N-[3-bromo-1-phenylsulfonylindol-2-ylmethyl]-N-methylaniline 
• 697285-15-7 N-[3-bromo-1-phenylsulfonylindol-2-ylmethyl]aniline 
• 488814-69-3 N-[3-bromo-1-phenylsulfonylindol-2-ylmethyl]-2'-bromoaniline 
• 697285-10-2 N-[3-bromo-1-phenylsulfonylindol-2-ylmethyl]-p-toluidine 
• 697285-17-9 N-[3-bromo-1-phenylsulfonylindol-2-ylmethyl]-4'-isopropylaniline 
• 510732-10-2 N-[3-bromo-1-phenylsulfonylindol-2-ylmethyl]-2'-bromo-4'-methylaniline 
• 80360-21-0 1-(benzenesulfonyl)-2-methyl-1H-indole 
• 85678-41-7 N-benzenesulphonyl-2-methyl-3-thiophenoxyindole 
• 887615-99-8 1-benzenesulfonyl-2-methyl-3-pyridin-4-yl-1H-indole 
• 871335-33-0 3-bromo-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde 
• 177274-67-8 3-bromo-2-(bromomethyl)-1-(phenylsulfonyl)-1H-indole 

Relevant academic research and scientific papers

Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) for the treatment of allergic inflammatory diseases

Previously we reported the discovery of CRA-898 (1), a diazine indole acetic acid containing CRTH2 antagonist. This compound had good in vitro and in vivo potency, low rates of metabolism, moderate permeability, and good oral bioavailability in rodents. H

A simple iodination protocol via in situ generated ICl using NaI/FeCl 3

A novel iodination of silyl-enol ethers using hitherto unexplored NaI/FeCl3 system is reported. The procedure has been extended to the iodination of aromatic and hetero aromatic compounds.

Low molecular weight indole fragments as IMPDH inhibitors

The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.

A Facile Synthesis of 3,4-Benzo-β-carbolines

A convenient method for the synthesis 3,4-benzo-β-carbolines (10) from the corresponding N-phenylsulfonyl-3-bromo-N′-arylisogramines (5) via radical mediated cyclization methodology has been reported.

Synthesis of 4-substituted-1,2,3,4-tetrahydro-β-carbolines via intramolecular radical cyclisation and Heck reaction

A convenient method for the synthesis of 4-substituted-β-carbolines from the corresponding N-allylisogramine derivative is reported using intramolecular free radical cyclisation or Heck reaction.