177407-16-8

Upstream product

• 1169393-52-5 2-[1-(1,3-benzothiazol-2-yl)ethyl]-1H-isoindole-1,3(2H)-dione 
• 177407-14-6 2-(α-Aminoethyl)-benzothiazole 
• 141-78-6 ethyl acetate 
• 1629-79-4 2-[1-(hydroxyimino)ethyl]-benzo[d]thiazole 

Downstream Products

• 3985-52-2 2-(α-Formamidoethyl)-benzothiazole 
• 1169393-54-7 (S)-1-(1,3-benzohiazol-2-yl)ethanamine 
• 1169393-55-8 (R)-N-[1-(1,3-benzothiazol-2-yl)ethyl]acetamide 
• 4089-98-9 N-(1-(benzo[d]thiazol-2-yl)ethyl)acetamide 

Relevant academic research and scientific papers

Stereoselective chemoenzymatic synthesis of enantiopure 1-(Heteroaryl)ethanamines by lipase-Catalysed kinetic resolutions

The efficient chemical synthesis and enzymatic kinetic resolution of a family of 1-(heteroaryl)ethanamines have been performed with lipases responsible for the preparation of nitrogenated compounds in high optical purity. Thus, Candida antarctica lipase type B has been identified as an excellent biocatalyst for the stereoselective production of the corresponding enantiomerically enriched (B)-acetamides and (S)-amines. A similar effect of the heteroatom in the cyclic ring has been observed in terms of reactivity and enantio- selectivity, with benzoxazole, benzothiazole and benzimidazole derivatives being obtained with excellent enantiopurities after one day of reaction. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009.