177409-16-4

Upstream product

• 15944-88-4 4-[N,N-bis(2-chloroethyl)amino]benzoyl chloride 
• 89088-56-2 methyl 1-methyl-3-aminopyrazole-5-carboxylate 
• 177409-15-3 methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrazole-5-carboxylate 

Downstream Products

• 223437-72-7 3-<1-methyl-3-<1-methyl-3-<1-methyl-3-<4-bis(2-chloroethyl)aminophenylamido>-pyrazole-5-carboxamido>pyrazole-5-carboxamido>>pyrazole-5-carboxylic acid 
• 223437-73-8 N-succinimidyl-<1-methyl-3-<1-methyl-3-<1-methyl-3-<4-bis(2-chloroethyl)aminophenylamido>-pyrazole-5-carboxamido>pyrazole-5-carboxamido>>pyrazole-5-carboxylate 
• 223437-71-6 methyl 3-<1-methyl-3-<1-methyl-3-<1-methyl-3-<4-bis(2-chloroethyl)aminophenylamido>-pyrazole-5-carboxamido>pyrazole-5-carboxamido>>pyrazole-5-carboxylate 

Relevant academic research and scientific papers

Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: Synthesis and antileukemic activity

The design and synthesis of novel benzoic acid mustard (BAM) derivatives of distamycin A bearing one or more pyrazole rings replacing the pyrrole rings of the latter are described. In vitro and in vivo activities against L1210 leukemia are reported and discussed. Some of these compounds show an activity profile comparable to tallimustine 1. All the compounds bearing the pyrazole ring close to the BAM moiety show reduced cytotoxicity in comparison to derivatives characterized by the BAM linked to a pyrrole: the same effect has not been observed when occurring at the amidine terminus of the oligopeptidic frame. Copyright (C) 1999 Elsevier Science Ltd.

Synthesis and antitumor activity of novel distamycin derivatives

Several distamycin derivatives were synthesized from deformyl distamycin by coupling with different azole carboxylic acids bearing an alkylating moiety. Some of them showed good activities in vitro and in vivo against L 1210 murine leukemia.