89088-56-2

Usage

Uses

Used in Pharmaceutical Industry:
METHYL-3-AMINO-1-METHYL PYRAZOLE-5-CARBOXYLATE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and functional groups contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL-3-AMINO-1-METHYL PYRAZOLE-5-CARBOXYLATE serves as a chemical intermediate in the production of agrochemicals. Its properties allow for the creation of compounds that can be used in pest control and crop protection, enhancing agricultural productivity and sustainability.
Used in Organic Synthesis:
METHYL-3-AMINO-1-METHYL PYRAZOLE-5-CARBOXYLATE is utilized as a versatile building block in organic synthesis. Its presence in various organic compounds makes it a valuable component in the development of new chemical entities with diverse applications across different industries.

InChI:InChI=1/C6H9N3O2/c1-9-4(6(10)11-2)3-5(7)8-9/h3H,1-2H3,(H2,7,8)

Upstream product

• 117860-58-9 methyl 3-<(benzyloxycarbonyl)amino>-1-methylpyrazole-5-carboxylate 
• 89088-54-0 5-carbomethoxy-3-(2,5-dimethylpyrrolyl)-1-methylpyrazole 
• 33146-99-5 methyl ester of 1-methylpyrazole-3,5-dicarboxylic acid 
• 117860-56-7 5-(methoxycarbonyl)-1-methyl-1H-pyrazole-3-carboxylic acid 
• 232281-29-7 1-methyl-5-methoxycarbonylpyrazole-3-carbonyl chloride 
• 1029512-15-9 5-Azidocarbonyl-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 796038-07-8 1-methyl-5-nitro-1H-pyrazole-3-carboxylic acid methyl ester 
• 177409-38-0 2-methyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester 
• 181585-93-3 5-nitro-2H-pyrazole-3-carboxylic acid methyl ester 

Downstream Products

• 177409-16-4 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrazole-5-carboxylic acid 
• 10250-64-3 2-Methyl-5-phenyl-2H-pyrazole-3-carboxylic acid 
• 1346669-68-8 5-[2-(hydroxymethyl)-3-(5-{[5-(2-hydroxypropan-2-yl)-1-methyl-1H-pyrazol-3-yl]amino}-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)phenyl]-8-thia-5-azatricyclo[7.4.0.0(2,7)]trideca-1⁽⁹⁾,2⁽⁷⁾-dien-6-one 
• 177409-38-0 2-methyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester 
• 177409-39-1 1-methyl-3-nitro-1H-pyrazole-5-carboxylic acid 

Relevant academic research and scientific papers

FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES

Provided are compounds according to any of Formula (I-1) to (I-7), pharmaceutical compositions comprising at least one of said compounds, their use as a medicament, and their use in treating chronic hepatitis B virus (HBV) infection. Methods for preparing compounds according to any of Formula (I-1) to (I-7) are also provided.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula A, or a pharmaceutically acceptable salt thereof, are featured (Formula A) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

SULPHONAMIDES AND COMPOSITIONS THEREOF FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: wherein the variables shown in Formula AA can be as defined anywhere herein. Compounds AA are modulators of NLRP1 and/or NLRP3

PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

PYRIDAZINONE GLUCOKINASE ACTIVATORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

Synthesis and Characterization of Masked Aminopyrazolecarboxylic Acid Synthons

The synthesis of the masked aminopyrazolecarboxylic acid synthons (11a,b and 12a,b) from pyrazole-3,5-dicarboxylic acid (6) and the determination of their structures by X-ray crystallography are detailed.The compounds are useful for the synthesis of polypyrazolecarboxamides analogous to the DNA minor groove binding antibiotics distamycin A and netropsin.

8-substituted pyrazolopentathiepins and related compounds

Heteropentathiepins including pyrazolopentathiepins substituted in the 8-position; intermediate pyrazolo-1,2,3-thiadiazoles, pyrazolothiazathiolium chlorides, and 5-substituted aminopyrazoles; process for making the pentathiepins by reacting the corresponding 1,2,3-thiadiazoles with sulfur at elevated temperatures; process for making the thiazathiolium chlorides; and use of the pentathiepins as fungicides or as sulfur sensitizers in photographic emulsions.

Pyrazolothiadiazoles from 3-Aminopyrazoles: The Hetero-Herz Reaction

The reaction of sulfur monochloride with pyrazoleamines gives good to excellent yields of pyrazolodithiazolium chlorides from a hetero-Herz reaction.No chlorination of the pyrazole nucleus was observed - a normal occurrence in Herz reactions.The Herz salts were converted to novel pyrazolothiadiazoles.