177409-39-1Relevant academic research and scientific papers
HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS
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Page/Page column 342, (2018/02/03)
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: Synthesis and antileukemic activity
Baraldi, Pier Giovanni,Cozzi, Paolo,Geroni, Cristina,Mongelli, Nicola,Romagnoli, Romeo,Spalluto, Giampiero
, p. 251 - 262 (2007/10/03)
The design and synthesis of novel benzoic acid mustard (BAM) derivatives of distamycin A bearing one or more pyrazole rings replacing the pyrrole rings of the latter are described. In vitro and in vivo activities against L1210 leukemia are reported and discussed. Some of these compounds show an activity profile comparable to tallimustine 1. All the compounds bearing the pyrazole ring close to the BAM moiety show reduced cytotoxicity in comparison to derivatives characterized by the BAM linked to a pyrrole: the same effect has not been observed when occurring at the amidine terminus of the oligopeptidic frame. Copyright (C) 1999 Elsevier Science Ltd.
Distamycin A analogues as antitumour or antiviral agents
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, (2008/06/13)
The present invention relates to compounds of formula (I) STR1 The compounds of the invention are useful as antitumor or antiviral agents.
