177532-29-5

Upstream product

• 88254-02-8 (R)-2-Ethyl-2-phenyl-malonic acid monomethyl ester 
• 177532-24-0 (R)-2-Hydroxymethyl-2-phenyl-butyric acid methyl ester 
• 177532-30-8 (S)-2-Methoxycarbonyloxycarbonyl-2-phenyl-butyric acid methyl ester 
• 88253-95-6 dimethyl 2-ethyl-2-phenylmalonate 
• 2613-89-0 phenylmalonic acid 
• 1636-25-5 (ethyl)phenylmalonic acid 
• 850805-72-0 methyl (S)-(+)-2-ethyl-2-phenylbut-3-enoate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 177532-28-4 methyl (R)-(+)-2-formyl-2-phenylbut-3-enoate 

Downstream Products

• 170450-73-4 (S)-(+)-2-ethyl-2-phenylglutaric acid 
• 17575-59-6 glutethimide 
• 177532-26-2 (S)-(+)-5-ethyl 1-methyl 2-ethyl-2-phenylglutarate 

Relevant academic research and scientific papers

Catalytic enantioselective synthesis of quaternary all-carbon stereogenic centers. Preparation of α,α′-disubstituted β,γ-unsaturated esters through Cu-catalyzed asymmetric allylic alkylations

(Chemical Equation Presented) Peptide-based chiral ligands, readily prepared from commercially available materials, are used to promote Cu-catalyzed asymmetric allylic alkylations of α,β-unsaturated esters bearing a γ-phosphate with various alkylzinc reagents. These transformations lead to the formation of α,α′-dialkyl-β,γ-unsaturated esters in high yields as well as high regio- (re) and enantloselectivities (ee).

Asymmetric construction of benzylic quaternary carbons from chiral malonates: Formal synthesis of both (-)- and (+)-aminoglutethimides AG and analogues

From a single chiron (R)-(+)-5, available with high enantiomeric excess (97%) by enzymatic hydrolysis (PLE acetonic powder) of a malonate, were prepared convenient precursors of aminoglutethimides (-)-AG-1 and (+)-AG-1. This versatile method also allows preparation of the b-hydroxy ester (R)-9 and its enantiomer (S)-9 as well as the glutethimides (S)-4 and (R)-4 and other analogues.