17762-33-3

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 105-37-3 Ethyl propionate 

Downstream Products

• 838855-30-4 4-[1-ethyl-7,8-bis(methyloxy)-3H-pyrazolo[3,4-c]isoquinolin-5-yl]phenol trifluoroacetate 
• 593279-05-1 C₁₃H₁₇N₃O₂ 
• 425398-91-0 1-phenyl-3-ethyl-4-(3,4-dimethoxyphenyl)-5-aminopyrazole 
• 332351-95-8 1-ethyl-3-phenyl-5-(3-pyridyl)-7,8-dimethoxypyrazolo[3,4-c]isoquinoline 

Relevant academic research and scientific papers

A versatile synthesis of pyrazolo[3,4-c]isoquinoline derivatives by reaction of 4-aryl-5-aminopyrazoles with aryl/heteroaryl aldehydes: The effect of the heterocycle on the reaction pathways

The reaction of 4-(3,4-dimethoxyphenyl)-5-aminopyrazoles 7A-D with aromatic and heterocyclic aldehydes in strong acidic media (trifluoroacetic or formic acid) has been studied. The initial azomethine derivatives 8 undergo cyclization similar to the Pictet

ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE

The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.