17767-01-0Relevant academic research and scientific papers
Palladium-catalyzed carbonylative synthesis of α,β-unsaturated amides from aryl azides and alkenylaluminum reagent
Chen, Bo,Wu, Xiao-Feng
, p. 160 - 163 (2020/02/11)
In this work, an interesting procedure for the synthesis of α,β-unsaturated amides from aryl azides and alkenylaluminum reagent has been developed. With palladium as the catalyst and XPhos as the ligand under carbon monoxide pressure, the desired α,β-unsaturated amides were isolated in good to excellent yields with good functional group tolerance. Remarkably, this procedure also represents an example on addition of organometallic reagent to isocyanates for α,β-unsaturated amides synthesis.
Preparations of Z-α,β-unsaturated amides by using Horner-Wadsworth-Emmons reagents (diphenylphosphono)acetamides
Ando
, p. 1272 - 1274 (2007/10/03)
New Horner-Wadsworth-Emmons reagents (diphenylphosphono)acetamides 2 react with a variety of aldehydes to give the corresponding Z-α,β-unsaturated amides stereoselectively (up to Z:E = 98: 2).
