177755-69-0

Basic information

• Product Name: 3,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile
• Synonyms: 3,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile
• CAS NO: 177755-69-0
• Molecular Weight: 241.313
• Mol File: 177755-69-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile(177755-69-0)
• EPA Substance Registry System: 3,4-difluoro-α-[(trimethylsilyl)oxy]benzeneacetonitrile(177755-69-0)

Safety Data

• Hazardous Substances Data: 177755-69-0(Hazardous Substances Data)

Upstream product

• 177755-45-2 2-(3-fluoro-4-methoxyphenyl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 34036-07-2 3,4 difluorobenzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 870862-12-7 C₁₄H₉F₂N 
• 177755-71-4 1-(3,4-difluorophenyl)-2-[4-(methylthio)phenyl]ethane-1,2-dione 
• 177755-70-3 1-(3,4-difluorophenyl)-2-hydroxy-2-[4-(methylthio)phenyl]-ethanone 

Relevant articles and documents

Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists

Optimization of high-throughput screening hit 1a led to the identification of a novel spiro-piperidine class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Compound 3c was identified as a highly potent and selective MCH-1R antagonist, which has an IC50 value of 0.09 nM at hMCH-1R. The synthesis and structure-activity relationships of the novel spiro-piperidine MCH-1R antagonists are described.