177755-73-6

Basic information

• Product Name: 2-hydroxy-2-(4-methylthiophenyl)-1-phenylethanone
• Synonyms: 2-hydroxy-2-(4-methylthiophenyl)-1-phenylethanone
• CAS NO: 177755-73-6
• Molecular Weight: 258.341
• Mol File: 177755-73-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-2-(4-methylthiophenyl)-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2-(4-methylthiophenyl)-1-phenylethanone(177755-73-6)
• EPA Substance Registry System: 2-hydroxy-2-(4-methylthiophenyl)-1-phenylethanone(177755-73-6)

Safety Data

• Hazardous Substances Data: 177755-73-6(Hazardous Substances Data)

Upstream product

• 3446-89-7 4-(Methylthio)benzaldehyde 
• 95392-03-3 2-(3,4-dichlorophenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 177755-55-4 1-(3,4-dichlorophenyl)-2-hydroxy-2-[4-(methylthio)phenyl]ethanone 
• 100-52-7 benzaldehyde 
• 532-28-5 (RS)-mandelonitrile 
• 1074-12-0 phenylglyoxal hydrate 
• 100-68-5 methyl-phenyl-thioether 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 1333394-49-2 (4-(methylthio)phenyl)(2-phenyl-1,3-dithian-2-yl)methanol 

Downstream Products

• 1333394-66-3 (S)-1-(4-(methylthio)phenyl)-2-oxo-2-phenylethyl butyrate 
• 1415020-19-7 C₁₆H₁₄N₂S₂ 
• 58022-58-5 1-(4-methylsulfanylphenyl)-2-phenyl-1,2-ethanedione 
• 177755-74-7 4-[4-(methylthio)phenyl]-5-phenyl-2-(trifluoromethyl)-1H-imidazole 

Relevant articles and documents

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors

A series of 4,5-diaryl-1H-imidazole-2(3H)-thione was synthesized and their inhibitory potency against soybean 15-lipoxygenase and free radical scavenging activities were determined. Compound 11 showed the best IC50 for 15-LOX inhibition (IC50 = 4.7 μM) and free radical scavenging activity (IC50 = 14 μM). Methylation of SH at C2 position of imidazole has dramatically decreased the 15-LOX inhibition and radical scavenging activity as it can be observed in the inactive compound 14 (IC50 >250 μM). Structure activity similarity (SAS) showed that the most important chemical modification in this series was methylation of SH group and Docking studies revealed a proper orientation for SH group towards Fe core of the 15-LOX active site. Therefore it was concluded that iron chelating could be a possible mechanism for enzyme inhibition in this series of compounds.

Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors

The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.