177787-25-6

Basic information

• Product Name: Benzoyl chloride, 4-chloro-3-fluoro- (9CI)
• Synonyms: Benzoyl chloride, 4-chloro-3-fluoro- (9CI);4-Chloro-3-fluorobenzoyl chloride 97%;3-Fluoro-4-chlorobenzoyl chloride;4-Chloro-3-fluorobenzoylchloride97%
• CAS NO: 177787-25-6
• Molecular Formula: C₇H₃Cl₂FO
• Molecular Weight: 193.0025232
• Product Categories: ACIDHALIDE
• Mol File: 177787-25-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 222℃
• Flash Point: 88℃
• Appearance: /
• Density: 1.462
• CAS DataBase Reference: Benzoyl chloride, 4-chloro-3-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 4-chloro-3-fluoro- (9CI)(177787-25-6)
• EPA Substance Registry System: Benzoyl chloride, 4-chloro-3-fluoro- (9CI)(177787-25-6)

Safety Data

• HazardClass: CORROSIVE
• Hazardous Substances Data: 177787-25-6(Hazardous Substances Data)

Usage

General Description

Benzoyl chloride, 4-chloro-3-fluoro- (9CI) is a chemical compound with the molecular formula C7H9ClFO. It is a clear, colorless to light yellow liquid with a pungent, irritating odor. Benzoyl chloride, 4-chloro-3-fluoro- (9CI) is commonly used in the pharmaceutical industry as a key building block for the synthesis of various active pharmaceutical ingredients, including anti-inflammatory drugs and antibiotics. It is also utilized as a chemical intermediate in the production of agrochemicals, dyes, and fragrances. Benzoyl chloride, 4-chloro-3-fluoro- (9CI) is highly reactive and should be handled with caution due to its potential to cause irritation to the eyes, skin, and respiratory system. Additionally, it is important to store and handle this compound in accordance with proper safety measures to prevent accidental exposure and potential hazards.

Upstream product

• 403-17-8 4-chloro-3-fluorobenzoic acid 

Downstream Products

• 582323-13-5 4-chloro-N-(2-chloropyrimidin-5-yl)-3-fluorobenzamide 
• 1027410-69-0 C₁₂H₇Cl₂FN₂O 

Relevant articles and documents

Novel hetero-cyclic compound and organic light emitting device comprising the same

The present invention relates to a novel heterocyclic compound, which is capable of increasing efficiency and lifetime in an organic light emitting device, and an organic light emitting device using the same. The novel heterocyclic compound is represented

N -pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy

A series of N-pyridyl benzamide KCNQ2/Q3 potassium channel openers were identified and found to be active in animal models of epilepsy and pain. The best compound 12 [ICA-027243, N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide] has an EC50 of 0.38 μM and is selective for KCNQ2/Q3 channels. This compound was active in several rodent models of epilepsy and pain but upon repeated dosing had a number of unacceptable toxicities that prevented further development. On the basis of the structure-activity relationships developed around 12, a second compound, 51, [N-(2-chloro-pyrimidin-5-yl)-3,4-difluoro- benzamide, ICA-069673], was prepared and advanced into a phase 1 clinical study. Herein, we describe the structure-activity relationships that led to the identification of compound 12 and to the corresponding pyrimidine 51.