875414-11-2Relevant academic research and scientific papers
Pyridobenzodiazepines: A novel class of orally active, vasopressin V 2 receptor selective agonists
Failli, Amedeo A.,Shumsky, Jay S.,Steffan, Robert J.,Caggiano, Thomas J.,Williams, David K.,Trybulski, Eugene J.,Ning, Xiaoping,Lock, Yeungwai,Tanikella, Tarak,Hartmann, David,Chan, Peter S.,Park
, p. 954 - 959 (2007/10/03)
Our efforts in seeking low molecular weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clinical candidate WAY-151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of potent, orally active, non-peptidic vasopressin V2 receptor selective agonists exemplified by the 5,11-dihydro-pyrido[2,3-b][1,5]benzodiazepine as a candidate for further development.
