177897-07-3

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 103258-64-6 ethyl 2-(4-hydroxymethylphenoxy)acetate 

Downstream Products

• 177897-08-4 [4-({[4-(2,2,2-Trifluoro-acetylamino)-butyl]-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid ethyl ester 
• 213008-40-3 [4-({(4-{tert-Butoxycarbonyl-[3-(2,2,2-trifluoro-acetylamino)-propyl]-amino}-butyl)-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Solid phase polyamine linkers - Their utility in synthesis and the preparation of directed libraries against trypanothione reductase

A variety of diprotected polyamines are anchored to a solid support and used in solid phase chemistry and library generation.

Solid phase synthesis of polyamine conjugates for the study of trypanothione reductase

A number of polyamine scaffolds were synthesised, enabling the facile preparation of a variety of polyamine conjugates using both Boc and Fmoc protecting group strategies. Products were released from the solid support by treatment with either triflic acid/trifluoroacetic acid or trifluoroacetic acid. The trypanosomal metabolite N1, N6-bis(glurathionyl)spermidine [trypanothione], and a range of related analogues were prepared for biological evaluation as previously communicated.