213008-40-3Relevant academic research and scientific papers
The synthesis of symmetrical spermine conjugates using solid-phase chemistry
Page, Patrick,Barrage, Sarah,Baldock, Lorraine,Bradley, Mark
, p. 1751 - 1756 (1998)
The utility of spermine, selectively functionalised and immobilised on a solid support by means of the Wang 'oxycarbonyl' linker is demonstrated by the solid-phase synthesis of a number of spermine conjugates including the natural product and potent antihypertensive agent kukoamine. The synthesis opens up the area of solid-phase spermine chemistry and library generation based on the symmetrical spermine scaffold.
