177948-74-2

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
(R)-N-(4-(1-AMINOETHYL)PHENYL)ACETAMIDE is used as a chemical intermediate for the synthesis of potential therapeutic agents. Its unique chemical structure allows it to be a promising candidate in the development of medications for various conditions. (R)-N-(4-(1-AMINOETHYL)PHENYL)ACETAMIDE's amide functional group and aminoethyl group may contribute to its potential pharmacological properties, making it valuable in the creation of new drugs.
Used in Synthesis of Medications for Various Conditions:
(R)-N-(4-(1-AMINOETHYL)PHENYL)ACETAMIDE is used as a building block in the synthesis of medications targeting a range of health issues. Its potential applications in medicine are still under investigation, but its chemical structure suggests that it could be a valuable component in the development of new treatments for various conditions.

Upstream product

• 694529-72-1 [1-(4-acetylamino-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 57233-86-0 d-(+)-α-methyl-4-nitrobenzylamine hydrochloride 
• 262368-44-5 (R)-[1-(4-aminophenyl)ethyl]carbamic acid tert-butyl ester 
• 694529-38-9 (R)-[1-(4-nitrophenyl)ethyl]carbamic acid t-butyl ester 

Relevant academic research and scientific papers

Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists

A series of chain-branched 1,3-dibenzylthiourea derivatives were synthesized, and tested their antagonist activity against vanilloid receptor 1. Chain-branching led to a significant change in the mode of action and the potency. (R)-Methyl or ethyl-branched 1,3-dibenzylthiourea derivatives showed the most potent antagonist activity up to the IC50 value of 0.05 μM which is 10-fold more potent than capsazepine.

3-[3-(piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists

Several 5-HT(ID/1B) receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT(1D)receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3-(piperidin-1-yl)propyl]indoles has been synthesized which has led to the identification of 80 (L-772,405), a high- affinity h5-HT(1D) receptor full agonist having 170-fold selectivity for h5- HT(1D) receptors over h5-HT(1B) receptors. L-772,405 also shows very good selectivity over a range of other serotonin and nonserotonin receptors and has excellent bioavailability following subcutaneous administration in rats. It therefore constitutes a valuable tool to delineate the role of h5-HT(1D) receptors in migraine. Molecular modeling and physical properties have been utilized to postulate the binding conformation of these compounds in the receptor cavity.