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[1-(4-acetylamino-phenyl)-ethyl]-carbamic acid tert-butyl ester, commonly known as tadalafil, is a pharmaceutical compound belonging to the phosphodiesterase type 5 (PDE5) inhibitors class. It is characterized by its ability to enhance blood flow to the penis during sexual stimulation, leading to a more sustained and robust erection. Tadalafil is available in oral tablet form and is recognized for its long-lasting effects, which can last up to 36 hours.

694529-72-1

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694529-72-1 Usage

Uses

Used in Pharmaceutical Industry:
Tadalafil is used as a medication for treating erectile dysfunction and benign prostatic hyperplasia. It functions by increasing blood flow to the penis, resulting in a longer-lasting and stronger erection during sexual stimulation. This makes tadalafil a popular choice for individuals seeking an extended-duration treatment option for erectile dysfunction.
Additionally, tadalafil has been found to have potential applications in other areas of medicine, such as treating pulmonary arterial hypertension and improving exercise capacity in patients with chronic obstructive pulmonary disease (COPD). However, these uses are not the primary focus of the provided materials and may require further research and clinical trials for validation.

Check Digit Verification of cas no

The CAS Registry Mumber 694529-72-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,4,5,2 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 694529-72:
(8*6)+(7*9)+(6*4)+(5*5)+(4*2)+(3*9)+(2*7)+(1*2)=211
211 % 10 = 1
So 694529-72-1 is a valid CAS Registry Number.

694529-72-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl (R)-(1-(4-acetamidophenyl)ethyl)carbamate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:694529-72-1 SDS

694529-72-1Relevant academic research and scientific papers

Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists

Ryu, Chong Hyun,Jang, Mi Jung,Jung, Jeong Wha,Park, Ju-Hyun,Choi, Hye Young,Suh, Young-Ger,Oh, Uhtaek,Park, Hyeung-Geun,Lee, Jeewoo,Koh, Hyun-Joo,Mo, Joo-Hyun,Joo, Yung Hyup,Park, Young-Ho,Kim, Hee-Doo

, p. 1751 - 1755 (2007/10/03)

A series of chain-branched 1,3-dibenzylthiourea derivatives were synthesized, and tested their antagonist activity against vanilloid receptor 1. Chain-branching led to a significant change in the mode of action and the potency. (R)-Methyl or ethyl-branched 1,3-dibenzylthiourea derivatives showed the most potent antagonist activity up to the IC50 value of 0.05 μM which is 10-fold more potent than capsazepine.

3-[3-(piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists

Russell, Michael G. N.,Matassa, Victor G.,Pengilley, Roy R.,Van Niel, Monique B.,Sohal, Bindi,Watt, Alan P.,Hitzel, Laure,Beer, Margaret S.,Stanton, Josephine A.,Broughton, Howard B.,Castro, José L.

, p. 4981 - 5001 (2007/10/03)

Several 5-HT(ID/1B) receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT(1D)receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3-(piperidin-1-yl)propyl]indoles has been synthesized which has led to the identification of 80 (L-772,405), a high- affinity h5-HT(1D) receptor full agonist having 170-fold selectivity for h5- HT(1D) receptors over h5-HT(1B) receptors. L-772,405 also shows very good selectivity over a range of other serotonin and nonserotonin receptors and has excellent bioavailability following subcutaneous administration in rats. It therefore constitutes a valuable tool to delineate the role of h5-HT(1D) receptors in migraine. Molecular modeling and physical properties have been utilized to postulate the binding conformation of these compounds in the receptor cavity.

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