17798-15-1

Upstream product

• 24395-14-0 N-(p-tolylsulfonyl)-2-phenylaziridine 
• 100-42-5 styrene 
• 127-65-1 chloroamine-T 
• 622-24-2 2-phenylethyl chloride 
• 70-55-3 toluene-4-sulfonamide 
• 473-34-7 N,N-dichloro-p-toluenesulfonamide 
• 593-71-5 Chloroiodomethane 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 20989-17-7 Phenylglycinol 

Relevant academic research and scientific papers

A phosphonium ylide as a visible light organophotoredox catalyst

A phosphonium ylide-based visible light organophotoredox catalyst has been designed and successfully applied to halohydrin synthesis using trichloroacetonitrile and epoxides. An oxidative quenching cycle by the ylide catalyst was established, which was confirmed by experimental mechanistic studies.

Use of trichloroacetonitrile as a hydrogen chloride generator for ring-opening reactions of aziridines

Regioselective ring-opening reactions of 2-aryl-N-tosylaziridines are described, in which hydrogen chloride is generated by photodegradation of trichloroacetonitrile. HCl adducts are obtained in high yields in 1,4-dioxane, whereas methanol adducts are pre

A versatile metal-free intermolecular aminochlorination of alkenes

New reaction conditions for the rapid and productive intermolecular aminochlorination reaction of alkenes using a combination of chloramine-T and a Br?nstedt acid are described. Upon simple protonation of chloramine-T, conditions for a mild and selective aminochlorination are obtained. In addition, the reaction can proceed to form either of the two possible regioisomers, depending on whether a stoichiometric amount of such an acid activator or acetic acid is used as solvent. The reaction is operative for all different classes of alkenes. A total of over 50 examples is presented to illustrate this concept.

An efficient method for opening N -tosylaziridines with silylated nucleophiles by using polystyrene-supported 1,5,7-triazabicyclo[44.0]dec-5-ene as a reusable organocatalyst

Polystyrene-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene (PS-TBD) catalyzes the ring opening of N-tosylaziridines with trimethylsilyl cyanide, trimethylsilyl azide, or trimethylsilyl halides to give the corresponding products in high yields. PS-TBD can b

Hydrated nickel (II) halides mediated ring opening reaction with N-tosylaziridines

An efficient and water tolerant method for the synthesis of β-haloamines is described utilizing hydrated nickel (II) halides (NiX 2·nH2O X = Cl, Br, I) and aziridines as starting materials. N-Tosylaziridines reacted with NiCl2/

A one-pot β-chloro-N′-tosylamidination of olefins with chloramine-T

A new method for the direct synthesis of β-chloro-N′- tosylamidines from olefins using chloramine-T and trifluoromethanesulfonic acid is described. Georg Thieme Verlag Stuttgart - New York.

Catalytic asymmetric chloroamination reaction of α,β-Unsaturated γ-keto esters and chalcones

Highly efficient catalytic chloroamination reaction of α,β- unsaturated γ-keto esters and chalcones has been developed via a chloronium-based mechanism to deliver anti-regioselective vicinal chloroamines instead of the aziridinium intermediates delivered

Transition-metal-free intermolecular amination of sp3 C-H bonds with sulfonamides

An efficient transition-metal-free intermolecular benzylic amidation with sulfonamides is described. Various valuable nitrogen-containing compounds, including amines, β-chloro amine, amino alcohol, α-, β-amino ester, and N-sulfonyl imine, are generated fr

Addition reactions of chloro- Or iodomethyllithium to imines. Synthesis of enantiopure aziridines and β-chloroamines

We report a novel, simple, and efficient synthesis of aziridines and l-chloroalkan-2-amines by the reaction of imines derived from various aldehydes and p-toluenesulfonamide or benzenesulfonamide with iodoor chloromethyllithium, respectively. Both halogenated anions were generated in situ by treatment of diiodo- or chloroiodomethane with methyllithium at -78 or 0 °C. The reaction of in situ generated iodoor chloromethyllithium could also be performed from chiral 2-aminoaldimines to yield enantiopure aziridines or (2S,3S)-2,3-diamino- l-chloroalkanes with high stereoselectivity.

Unprecedented CO2-promoted aminochlorination of olefins with Chloramine-T

A new synthetic procedure for the aminochlorination of olefins for the synthesis of vicinal chloroamine derivatives using a combination of Chloramine-T and carbon dioxide is described. The method can be applied to a variety of olefins, including an electr