1780-40-1

Basic information

• Product Name: 2,4,5,6-Tetrachloropyrimidine
• Synonyms: 2,4,5,6-tetrachloro-pyrimidin;perchloropyrimidine;tetrachloro-pyrimidin;tetrachloropyrimidine;2,4,5,6-TETRACHLOROPYRIMIDINE;Tetrachlorpyrimidin;2,4,5,6-Tetrachloropyrimidine,97%;2,4,5,6-TetrachloropyriMidine, 97% 5GR
• CAS NO: 1780-40-1
• Molecular Formula: C₄Cl₄N₂
• Molecular Weight: 217.87
• EINECS: 217-228-3
• Product Categories: FINE Chemical & INTERMEDIATES;pharmacetical;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 1780-40-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 68-70 °C(lit.)
• Boiling Point: 108 °C
• Flash Point: 133.2 °C
• Appearance: White/Crystalline Powder
• Density: 1.7673 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -8.56±0.39(Predicted)
• CAS DataBase Reference: 2,4,5,6-Tetrachloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5,6-Tetrachloropyrimidine(1780-40-1)
• EPA Substance Registry System: 2,4,5,6-Tetrachloropyrimidine(1780-40-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-27-37/39-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UV9745000
• Hazardous Substances Data: 1780-40-1(Hazardous Substances Data)

Usage

Chemical Properties

Beige crystals and chunks

InChI:InChI=1/C4Cl4N2/c5-1-2(6)9-4(8)10-3(1)7

Upstream product

• 67-52-7 BARBITURIC ACID 
• 444-15-5 5-hydroxybarbituric acid 
• 1738-25-6 3-dimethylaminopropiononitrile 
• 106351-49-9 dilituric acid 
• 21428-20-6 5,6-dichloro-1H-pyrimidine-2,4-dione 
• 10026-13-8 phosphorus pentachloride 
• 10025-87-3 trichlorophosphate 
• 61066-33-9 pyrimidine-2,4,5,6(1H,3H)-tetraone 

Downstream Products

• 90845-52-6 4-(4-nitrophenylamino)-2,5,6-trichloropyrimidine 
• 1239984-50-9 C₁₀H₄Cl₃FN₂ 
• 1239984-31-6 C₄₀H₂₇ClN₂ 
• 1239984-21-4 C₅₂H₃₆N₂ 
• 1239984-09-8 C₃₂H₂₈N₂ 
• 1239984-39-4 C₁₈H₁₄Cl₂N₂ 
• 1239984-48-5 C₁₁H₇Cl₃N₂ 
• 1239984-13-4 C₃₂H₂₈N₂O₄ 
• 1239984-15-6 C₂₈H₁₆F₄N₂ 
• 1239984-40-7 2,5-dichloro-4,6-bis(4-methoxyphenyl)pyrimidine 
• 1239984-49-6 2,4,5-trichloro-6-(4-methoxyphenyl)pyrimidine 
• 1239984-11-2 C₃₆H₃₆N₂ 
• 1239984-51-0 2,4,5-trichloro-6-(2-methoxyphenyl)pyrimidine 
• 1239984-37-2 C₂₅H₁₂ClF₉N₂ 

Relevant articles and documents

9- (PYRAZOL- 3 -YL) - 9H- PURINE-2 -AMINE AND 3- (PYRAZ0L-3-YL) -3H-IMIDAZ0 [4, 5-B] PYRIDIN-5-AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.

Method of preparing 4,5,6-trichloro- and 2,4,5,6-tetrachloropyrimidine

PCT No. PCT/EP97/02933 Sec. 371 Date Dec. 7, 1998 Sec. 102(e) Date Dec. 7, 1998 PCT Filed Jun. 6, 1997 PCT Pub. No. WO97/47605 PCT Pub. Date Dec. 18, 1997The invention relates to a process for the preparation of 4,5,6-trichloro- and 2,4,5,6-tetrachloropyr

Process for the preparation of tetrachloropyrimidine

Process for the preparation of tetrachloropyrimidine, characterized in that 2-cyanoethyl isocyanide dichloride is reacted with chlorine in the gas phase in the temperature range from 200°-650° C.