178056-76-3Relevant academic research and scientific papers
Mixed AuPd Nanoparticles as Highly Active Catalysts for Alkyne Z-Semihydrogenation
Wissing, Maren,Niehues, Maximilian,Ravoo, Bart Jan,Studer, Armido
supporting information, p. 3403 - 3409 (2018/07/25)
A method for the preparation of mixed AuPd nanoparticles that are used as catalysts for selective alkyne Z-semihydrogenation is described. It is shown that the corresponding monometallic Pd nanoparticles display a lower activity, documenting the cooperative effect exerted by the two metals. These mixed AuPd nanoalloys are readily prepared by irradiation of the corresponding precursor salts in the presence of photoactive polymers or commercially available photoinitiators as reducing and stabilizing agents. Alkyne semihydrogenation using these catalyst systems with H2 proceeds in high yield (up to 97 % yield of isolated product) and excellent Z-selectivity (up to 99 %). Hydrogenations work on larger scale and the hybrid catalyst can be recovered and reused by simple centrifugation.
Regio- and Stereoselective Cyanotriflation of Alkynes Using Aryl(cyano)iodonium Triflates
Wang, Xi,Studer, Armido
supporting information, p. 2977 - 2980 (2016/03/19)
A novel, mild, and versatile approach for regioselective syn-addition of both the CN and OTf groups of aryl(cyano)iodonium triflates to alkynes is described. The reaction uses Fe-catalysis and can be conducted in gram scale. Products of the vicinal cyanotriflation can be stereospecifically readily further functionalized, rendering the method highly valuable.
4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3- receptor antagonists with high oral central nervous system activity
Krause,Ligneau,Stark,Garbarg,Schwartz,Schunack
, p. 4171 - 4176 (2007/10/03)
In search for potent and therapeutically useful H3-receptor antagonists, we prepared novel 4-alkynylphenyl ether derivatives of 3-(1H- imidazol-4-yl)propanol in a convenient synthetic route. All compounds were tested for in vitro and in vivo H
