98491-29-3Relevant academic research and scientific papers
NOVEL THYROMIMETICS
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Page/Page column 100, (2020/09/19)
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, X1, X2, Q, R1, R2 and n are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
Triazole compounds as well as preparation method and application thereof
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Paragraph 0490-0491; 0495-0497, (2020/07/29)
The invention belongs to the technical field of medicinal chemistry, and particularly relates to triazole compounds and a preparation method and application thereof. The triazole compounds have excellent LPAR1 antagonistic activity and selectivity, are lo
BORON-CONTAINING SMALL MOLECULES
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Paragraph 0579, (2017/09/19)
Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.
Enantioselective Anion Recognition by Chiral Halogen-Bonding [2]Rotaxanes
Lim, Jason Y. C.,Marques, Igor,Félix, Vítor,Beer, Paul D.
supporting information, p. 12228 - 12239 (2017/09/12)
The application of chiral interlocked host molecules for discrimination of guest enantiomers has been largely overlooked, which is surprising given their unique three-dimensional binding cavities capable of guest encapsulation. Herein, we combined the stringent linear geometric interaction constraints of halogen bonding (XB), the noncovalent interaction between an electrophilic halogen atom and a Lewis base, with highly preorganized and conformationally restricted chiral cavities of [2]rotaxanes to achieve enantioselective anion recognition. Representing the first detailed investigation of the use of chiral XB rotaxanes for this purpose, extensive 1H NMR binding studies and molecular dynamics (MD) simulation experiments revealed that the chiral rotaxane cavity significantly enhances enantiodiscrimination compared to the non-interlocked free axle and macrocycle components. Furthermore, by examining the enantioselectivities of a family of structurally similar XB [2]rotaxanes containing different combinations of chiral and achiral macrocycle and axle components, the dominant influence of the chiral macrocycle in our rotaxane design for determining the effectiveness of chiral discrimination is demonstrated. MD simulations reveal the crucial geometric roles played by the XB interactions in orientating the bound enantiomeric anion guests for chiral selectivity, as well as the critical importance of the anions' hydration shells in governing binding affinity and enantiodiscrimination.
OXIME DERIVATIVE, METHOD OF PRODUCING THE SAME AND INSECTICIDE COMPRISING THE SAME AS ACTIVE INGREDIENT
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Paragraph 0178-0180, (2018/10/03)
PROBLEM TO BE SOLVED: To provide a compound having excellent insecticidal effect and useful as an active ingredient of an insecticide. SOLUTION: This invention provides an oxime derivative represented by general formula (1) (where Ra, X and n represent definitions described in the specifications) and an insecticide that comprises the same as an active ingredient. COPYRIGHT: (C)2015,JPOandINPIT
NOVEL WATER-SOLUBLE COMPLEXING AGENTS AND CORRESPONDING LANTHANIDE COMPLEXES
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Paragraph 0148, (2015/12/30)
The invention relates to complexing agents of formula (I): in which A, chrom1, chrom2 and chrom3 are as defined in the description. The invention also relates to the lanthanide complexes obtained from these complexing agents.
Total synthesis of the biphenyl alkaloid (-)-lythranidine
Gebauer, Konrad,Fuerstner, Alois
supporting information, p. 6393 - 6396 (2014/06/24)
A sequence comprising a ring-closing alkyne metathesis of a propargyl alcohol derivative, followed by a ruthenium-catalyzed redox isomerization of the derived cycloalkyne and a transannular aza-Michael addition allowed the formation of the distinguishing
Refrigerator
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, (2007/10/12)
The present invention relates to a refrigerator, including: a refrigerating cycle having an evaporator (1a); a space for exchanging heat with the evaporator; a region for exchanging heat between the evaporator and the space; and a storage chamber and a door for defining the space, wherein at least one of the region, the storage chamber and the door has undergone at least one of a Kimchi lactic acid bacteria culture treatment and a Kimchi lactic acid bacteria culture exposure treatment.
Diphenyltriacetylenes: Novel nematic liquid crystal materials and analysis of their nematic phase-transition and birefringence behaviours
Arakawa, Yuki,Kang, Sungmin,Nakajima, Shunpei,Sakajiri, Koichi,Cho, Yokan,Kawauchi, Susumu,Watanabe, Junji,Konishi, Gen-Ichi
, p. 8094 - 8102 (2014/01/06)
Improvements in birefringence properties of LC materials are actively being pursued because of the increase in their applications in optical devices. 1,6-Diphenyl-1,3,5-hexatriyne, i.e., diphenyltriacetylenes (DPTAs; number of acetylene units, n = 3) are
Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers
Flaherty, Daniel P.,Kiyota, Tomomi,Dong, Yuxiang,Ikezu, Tsuneya,Vennerstrom, Jonathan L.
supporting information; experimental part, p. 7992 - 7999 (2011/03/19)
Starting from bisphenolic bis-styrylbenzene DF-9 (4), β-amyloid (Aβ) binding affinity and specificity for phenolic bis-styrylbenzenes, monostyrylbenzenes, and alkyne controls were determined by fluorescence titration with β-amyloid peptide Aβ1-40 and a fluorescence assay using APP/PS1 transgenic mouse brain sections. Bis-styrylbenzene SAR is derived largely from work on symmetrical compounds. This study is the first to describe Aβ binding data for bis-styrylbenzenes unsymmetrical in the outer rings. With one exception, binding affinity and specificity were decreased by adding and/or changing the substitution pattern of phenol functional groups, changing the orientation about the central phenyl ring, replacing the alkene with alkyne bonds, or eliminating the central phenyl ring. The only compound with an Aβ binding affinity and specificity comparable to 4 was its 3-hydroxy regioisomer 8. Like 4, 8 crossed the blood-brain barrier and bound to Aβ plaques in vivo. By use of a DPPH assay, phenol functional groups with para orientations seem to be a necessary, but insufficient, criterion for good free radical scavenging properties in these compounds.
