178111-56-3

Upstream product

• 24686-78-0 1-Benzoyl-4-piperidone 
• 98-88-4 benzoyl chloride 
• 73390-11-1 4-piperidinone monohydrate 

Downstream Products

• 1194657-41-4 1-benzoyl-4-nitrosopiperidin-4-yl 2,2,2-trifluoroacetate 
• 178111-67-6 C₃₇H₄₆N₅O₁₄P 
• 178111-57-4 (4-Hydroxyamino-piperidin-1-yl)-phenyl-methanone 

Relevant academic research and scientific papers

Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity

The nucleoside analogue 1 incorporating a [P(O)-O-N] linkage was synthesized as a hapten to obtain catalytic antibodies may cleave a phosphodiester bond. Secondary alcohol 15 was successfully phosphorylated with the phosphodiester derived from hydroxylamine derivative 7b to give a protected form of the hapten. Deprotection was accomplished using Pd-catalyzed deallylation that afforded hapten 1 after HPLC purification.

NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF

The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.