178111-57-4Relevant academic research and scientific papers
Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity
Sakurai, Mitsuya,Wirsching, Peter,Janda, Kim D.
, p. 1055 - 1060 (2007/10/03)
The nucleoside analogue 1 incorporating a [P(O)-O-N] linkage was synthesized as a hapten to obtain catalytic antibodies may cleave a phosphodiester bond. Secondary alcohol 15 was successfully phosphorylated with the phosphodiester derived from hydroxylamine derivative 7b to give a protected form of the hapten. Deprotection was accomplished using Pd-catalyzed deallylation that afforded hapten 1 after HPLC purification.
