17815-88-2

Usage

Uses

Used in Organic Synthesis:
[bromo(fluoro)methyl]benzene is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions. Its unique combination of bromine and fluorine atoms allows it to participate in a wide range of reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, [bromo(fluoro)methyl]benzene is utilized as an intermediate in the production of various drugs. Its presence in the synthesis process can contribute to the development of new medications with improved efficacy and reduced side effects.
Used in Agrochemical Production:
[bromo(fluoro)methyl]benzene also finds application in the agrochemical sector, where it is employed as an intermediate in the synthesis of pesticides and other agricultural chemicals. Its role in this industry is crucial for the development of effective and environmentally friendly products to protect crops and enhance agricultural productivity.
Safety Measures:
Given the hazardous nature of [bromo(fluoro)methyl]benzene, it is imperative to implement appropriate safety measures during its handling and use. This includes wearing personal protective equipment (PPE) such as gloves, goggles, and masks to minimize the risk of skin and eye irritation, as well as inhalation of the compound. Additionally, proper storage and disposal protocols should be followed to ensure the safety of both individuals and the environment.

Upstream product

• 87282-19-7 3-fluoro-3-phenyldiazirine 
• 455-31-2 difluoromethylbenzene 
• 100-39-0 benzyl bromide 
• 513-35-9 2-methyl-but-2-ene 
• 107-13-1 acrylonitrile 
• 350-50-5 benzyl fluoride 

Downstream Products

• 772339-79-4 α,α-dibromo-α-fluorotoluene 
• 79617-87-1 erythro-3-fluoro-3-phenylalanine 
• 57362-93-3 threo-DL-β-fluorophenylalanine 
• 98379-10-3 2-Amino-3-fluoro-3-phenyl-propionic acid benzyl ester 
• 98379-10-3 2-Amino-3-fluoro-3-phenyl-propionic acid benzyl ester 
• 59729-21-4 2-Amino-3-fluoro-3-phenyl-propionic acid; hydrochloride 
• 59729-21-4 2-Amino-3-fluoro-3-phenyl-propionic acid; hydrochloride 
• 1260586-79-5 C₁₃H₁₇FO₆ 
• 93-98-1 N-phenyl benzoyl amide 
• 51229-66-4 [fluoro(phenyl)(phenylsulfonyl)]methane 
• 98379-08-9 2-(Benzhydrylidene-amino)-3-fluoro-3-phenyl-propionic acid benzyl ester 
• 98379-08-9 2-(Benzhydrylidene-amino)-3-fluoro-3-phenyl-propionic acid benzyl ester 
• 17815-89-3 1-Fluor-1-phenyl-tetramethyl-cyclopropan 

Relevant academic research and scientific papers

Modulation of selectivity in a fluorocarbene cyclopropanation reaction: a catalytic role for bromide ion

Phenylfluorocarbene is diverted to phenylfluorobromomethide carbanion (PhCFBr-) by adding bromide ion. The carbanion adds to acrylonitrile leading, after expulsion of bromide, to 1-fluoro-1-phenyl-2-cyanocyclopropane.

FLP-Catalyzed Monoselective C-F Functionalization in Polyfluorocarbons at Geminal or Distal Sites

We report frustrated Lewis pair (FLP)-catalyzed monoselective C-F activation in a range of aliphatic polyfluorocarbons with equivalent geminal and distal C-F positions. This methodology can be applied to aromatic-, ether-, thioether-, and alkyl-supported fluoromethyl groups. We expand the range of FLP base partners that work with monoselective C-F activation to include sulfide. The activated products can be subsequently functionalized via SN2 substitutions, photoredox-alkylations, and Suzuki couplings.

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

C-ARYL GLYCOSIDE COMPOUNDS FOR THE TREATMENT OF DIABETES AND OBESITY

This invention relates to a compound of generic formula (I): (I) as well as a pharmaceutically acceptable salt thereof, a tautomer, optical isomer or a mixture of optical isomers in any proportion, in particular a mixture of enantiomers, and particularly a racemate mixture, in particular for use thereof as a drug, notably in the treatment of diabetes.

MECHANISMS OF FREE-RADICAL REACTIONS. XX. REACTIVITY IN THE FREE-RADICAL HALOGENATION REACTIONS OF ARYLFLUOROALKANES

The free-radical chlorination and bromination of meta- and para-substituted benzyl fluorides and 1,1-difluoro-2-phenylethane and also the chlorination of 1-fluoro-2-arylethanes by phenylchloroiodonium chloride and the bromination of meta- and para-substituted benzyl bromides were studied by the method of competing reactions.In all cases a good correlation is observed between log krel and the Brown ?+ constants.In cases where change in the reactivity in the transition from one reaction series to another is due mainly to the polar effect of the substituent whilethe selectivity is measured in relation to the polar effect direct relationships are observed between the reactivity and the selectivity.