455-31-2

Basic information

• Product Name: (DIFLUOROMETHYL)BENZENE
• Synonyms: Benzalfluoride,a,a-Difluorotoluene;Benzylidene fluoride;(Difluoromethyl)benzene 97%;Benzene,(difluoromethyl)-
• CAS NO: 455-31-2
• Molecular Formula: C₇H₆F₂
• Molecular Weight: 128.1204
• Mol File: 455-31-2.mol
• Article Data: 59

Chemical Properties

• Boiling Point: 135°C(lit.)
• Flash Point: 35℃
• Appearance: /
• Density: 1.138 g/mL at 25 °C
• Refractive Index: n20/D1.458
• CAS DataBase Reference: (DIFLUOROMETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: (DIFLUOROMETHYL)BENZENE(455-31-2)
• EPA Substance Registry System: (DIFLUOROMETHYL)BENZENE(455-31-2)

Safety Data

• Hazard Codes: Xi,C
• Statements: 10-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2920 3(8) / PGII
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: II
• Hazardous Substances Data: 455-31-2(Hazardous Substances Data)

Usage

General Description

(Difluoromethyl)benzene, also known as 1,2-difluorotoluene, is a chemical compound with the molecular formula C7H6F2. It is a colorless liquid that is primarily used as an intermediate in the production of agrochemicals, pharmaceuticals, and dyes. (Difluoromethyl)benzene is classified as a hazardous chemical due to its flammable nature and potential health effects such as irritation to the skin, eyes, and respiratory system. It is important to handle and store this chemical with caution and observe safety protocols to prevent any accidents or exposure to its harmful effects.

Upstream product

• 98-87-3 benzylidene dichloride 
• 100-52-7 benzaldehyde 
• 150-60-7 dibenzyl disulphide 
• 100-42-5 styrene 
• 349-50-8 (chlorodifluoromethyl)benzene 
• 111-34-2 -butyl vinyl ether 
• 629-05-0 n-octyne 
• 111-66-0 oct-1-ene 
• 542-92-7 cyclopenta-1,3-diene 
• 536-74-3 phenylacetylene 
• 353-50-4 Carbonyl fluoride 
• 766-92-7 [(methylthio)methyl]-benzene 
• 5425-44-5 2-Phenyl-[1,3]dithiane 
• 108-88-3 toluene 

Downstream Products

• 349-50-8 (chlorodifluoromethyl)benzene 
• 83170-17-6 a-bromo-a,a-difluorotoluene 
• 329-29-3 cyclohexylmethylene difluoride 
• 82166-21-0 methyl cyclohexane 
• 100-52-7 benzaldehyde 
• 1644-16-2 phenyldifluoromethyl isocyanate 
• 22235-32-1 [(difluorophenylmethyl)sulfanyl]benzene 
• 114467-84-4 α,α-difluorobenzyl phenyl ether 
• 114467-94-6 (Difluoro-isothiocyanato-methyl)-benzene 
• 114467-97-9 (Difluoro-thiocyanato-methyl)-benzene 
• 114467-89-9 Ph-CF₂-N₃ 
• 137742-73-5 2-(phenyl)-2,2-difluoro-1,1-diphenylethan-1-ol 
• 1494-20-8 2,2-difluoro-1,2-diphenylethan-1-ol 
• 34472-86-1 1-(difluoro(phenyl)methyl)-4-nitrobenzene 

Relevant articles and documents

One-Electron Reductive Cleavage of the C-Cl Bond of ArCF2Cl: Convenient Route for the Synthesis of ArCF2 Derivatives

When ArCF2Cl was reacted with PhSeNa in DMF in the presence of light, it was found that a SRN1 type reaction occurred to give ArCF2SePh. As the reaction did not proceed without light, the substitution reaction should be in

Catalytic fluorination of dichloromethylbenzene by HF in liquid phase. Preparation of fluorinated building blocks

The selective fluorination by successive Cl/F exchanges of the dichloromethylbenzene, was studied in the presence of HF as the fluorinating agent. The influence of the presence of a catalyst or a basic solvent (such as dioxane, pyridine, tributylphosphate

A NEW METHOD OF 18F LABELLING AND INTERMEDIATE SALTS

Disclosed herein is a salt of formula I: where R1, X, n, R, R1, Y, m, p, q, Z and o are as defined herein. Also disclosed herein are methods of using said salts in chemical synthesis, such as to prepare compounds isotopically enriched in 18F for use in PET imaging, as well as methods to make the compounds of formula I.

PROCESSES FOR FLUORINATION

The present technology relates to fluorination reactions. Specifically, processes useful for making the fungicide compound, DFT are disclosed. More broadly, also disclosed herein are processes useful for deoxyfluorination at the α-aromatic position of a given compound.

METHOD AND REAGENT FOR DEOXYFLUORINATION

A safe, simple, and selective method and reagent for deoxyfluorination is disclosed. With the method and reagent disclosed herein, organic compounds such as carboxylic acids, carboxylates, carboxylic acid anhydrides, aldehydes, and alcohols can be fluorinated by using the most common nucleophilic fluorinating reagents and electron deficient fluoroarenes as mediators under mild conditions, giving corresponding fluoroorganic compounds in excellent yield with a wide range of functional group compatibility and easy product purification. For example, directly utilizing KF for deoxyfluorination of carboxylic acids provides the most economical and the safest pathway to access acyl fluorides, key intermediates for syntheses of peptide, amide, ester, and dry fluoride salts.