17817-56-0Relevant academic research and scientific papers
Substituent effects in ring-chain tautomerism of the condensation products of non-racemic 1,2-aminoalcohols with aromatic aldehydes
Juhasz, Marta,Lazar, Laszlo,Fueloep, Ferenc
experimental part, p. 2012 - 2017 (2012/03/22)
The condensation of (S)-2-amino-2-phenylethanol or (S)-2-amino-3- phenylpropanol with substituted benzaldehydes in methanol or water led to crystalline products, which proved to exist in CDCl3 at 300 K as three-component (ringcis-ope
A novel one-pot procedure for the stereoselective synthesis of α-hydroxy esters from ortho esters
Breunlng, Matthias,Haeuser, Tobte,Tanzer, Eva-Maria
supporting information; experimental part, p. 4032 - 4035 (2009/12/09)
A novel one-pot procedure for the stereoselective synthesis of a-hydroxy esters from ortho esters was developed. Key steps were multiheteroatom Cope rearrangements of O-acylated N-hydroxy-L-tert-leucinol-derived oxazoline N-oxides leading to a-acyloxy oxazolines and, after methanolysis, to the target molecules in 67-80% yield and 94-98% ee.
