178181-55-0

Basic information

• Product Name: tert-butyl 4-fluoropiperidine-1-carboxylate
• Synonyms: tert-butyl 4-fluoropiperidine-1-carboxylate;4-Fluoropiperidine-N-carboxylic acid tert-butyl ester;Boc-4-fluoropiperidine
• CAS NO: 178181-55-0
• Molecular Formula: C₁₀H₁₈FNO₂
• Molecular Weight: 203.2538232
• Mol File: 178181-55-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-fluoropiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-fluoropiperidine-1-carboxylate(178181-55-0)
• EPA Substance Registry System: tert-butyl 4-fluoropiperidine-1-carboxylate(178181-55-0)

Safety Data

• Hazardous Substances Data: 178181-55-0(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-fluoropiperidine-1-carboxylate is a chemical compound that belongs to the class of piperidine derivatives. It is a white solid substance with the molecular formula C12H20FNO2. tert-butyl 4-fluoropiperidine-1-carboxylate is commonly used in organic synthesis and pharmaceutical research as a building block for the preparation of various biologically active compounds. Its unique structure and properties make it a valuable intermediate for the development of new drugs and agrochemicals. Additionally, it can be utilized in the production of flavors and fragrances due to its potential as a versatile precursor. However, it is important to handle and use this compound with care, as it may pose health and environmental risks if not properly managed.

Upstream product

• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 78197-27-0 4-fluoropiperidine 
• 201230-82-2 carbon monoxide 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1311255-53-4 5-(4-fluorophenyl)-3-(4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole 
• 1311183-00-2 4-(4-fluoropiperidin-1-yl)-N'-hydroxy-3-(trifluoromethyl)benzimidamide 
• 1311232-61-7 5-[3-(4-fluoro-3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-2-(4-fluoro-piperidin-1-yl)-benzonitrile 
• 1311232-60-6 5-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-2-(4-fluoro-piperidin-1-yl)-benzonitrile 
• 1311255-52-3 3-cyano-4-(4-fluoro-piperidin-1-yl)-benzoic acid 
• 1159983-87-5 4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile 
• 78197-27-0 4-fluoropiperidine 

Relevant articles and documents

Sustainable Route Toward N-Boc Amines: AuCl3/CuI-Catalyzed N-tert-butyloxycarbonylation of Amines at Room Temperature

N-tert-butoxycarbonyl (N-Boc) amines are useful intermediates in synthetic/medicinal chemistry. Traditionally, they are prepared via an indirect phosgene route with poor atom economy. Herein, a step- and atom-economic synthesis of N-Boc amines from amines, t-butanol, and CO was reported at room temperature. Notably, this N-tert-butyloxycarbonylation procedure utilized ready-made substrates, commercially available AuCl3/CuI as catalysts, and O2 from air as the sole oxidant. This catalytic system provided unique selectivity for N-Boc amines in good yields. More significantly, gram-scale preparation of medicinally important N-Boc amine intermediates was successfully implement, which demonstrated a potential application prospect in industrial syntheses. Furthermore, this approach also showed good compatibility with tertiary and other useful alcohols. Investigations of the mechanisms revealed that gold catalyzed the reaction and copper acted as electron transfer mediator in the catalytic cycle.

NOVEL OXADIAZOLE COMPOUNDS

Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation o

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A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.