178204-50-7

Basic information

• Product Name: 2-METHYLSULFONYL-5-TRIFLUOROMETHYLPYRIDINE
• Synonyms: 2-METHYLSULFONYL-5-TRIFLUOROMETHYLPYRIDINE
• CAS NO: 178204-50-7
• Molecular Formula: C₇H₆F₃NO₂S
• Molecular Weight: 225.19
• Mol File: 178204-50-7.mol

Chemical Properties

• Melting Point: 133-136°C
• Appearance: /
• CAS DataBase Reference: 2-METHYLSULFONYL-5-TRIFLUOROMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLSULFONYL-5-TRIFLUOROMETHYLPYRIDINE(178204-50-7)
• EPA Substance Registry System: 2-METHYLSULFONYL-5-TRIFLUOROMETHYLPYRIDINE(178204-50-7)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• Hazardous Substances Data: 178204-50-7(Hazardous Substances Data)

Upstream product

• 76041-72-0 2-mercapto-5-trifluoromethylpyridine 
• 650592-47-5 2-(methylthio)-5-(trifluoromethyl)pyridine 

Downstream Products

• 188527-56-2 2-phenyl-5-(trifluoromethyl)pyridine 

Relevant articles and documents

Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone

A novel nickel-catalyzed reductive cross-coupling between aryl iodides and difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) enables C(sp2)-C(sp2) bond formation through selective C(sp2)-S bond cleavage, which demonstrates the new reactivity of 2-PySO2CF2H reagent. This method employs readily available nickel catalyst and sulfones as cross-electrophile coupling partners, providing facile access to biaryls under mild reaction conditions without pregeneration of arylmetal reagents.

Transition-Metal-Free Desulfinative Cross-Coupling of Heteroaryl Sulfinates with Grignard Reagents

A mild cross-coupling reaction of heteroaryl sulfinates with Grignard reagents has been developed under transition-metal-free conditions. This study provides an example of the SO22- as a leaving group in an aromatic system and an effective methodology for the construction of C-C bond.