188527-56-2

Basic information

• Product Name: PYRIDINE, 2-PHENYL-5-(TRIFLUOROMETHYL)-
• Synonyms: 2-PHENYL-5-TRIFLUOROMETHYL-PYRIDINE;PYRIDINE, 2-PHENYL-5-(TRIFLUOROMETHYL)-
• CAS NO: 188527-56-2
• Molecular Formula: C₁₂H₈F₃N
• Molecular Weight: 223.196
• Mol File: 188527-56-2.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 266.4 °C at 760 mmHg
• Flash Point: 114.9 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 0.0143mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: 2-8°C
• CAS DataBase Reference: PYRIDINE, 2-PHENYL-5-(TRIFLUOROMETHYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE, 2-PHENYL-5-(TRIFLUOROMETHYL)-(188527-56-2)
• EPA Substance Registry System: PYRIDINE, 2-PHENYL-5-(TRIFLUOROMETHYL)-(188527-56-2)

Safety Data

• Hazardous Substances Data: 188527-56-2(Hazardous Substances Data)

Usage

General Description

PYRIDINE, 2-PHENYL-5-(TRIFLUOROMETHYL)- is a chemical compound with a molecular formula C13H8F3N. It is a heterocyclic aromatic compound with a pyridine ring substituted with a phenyl group at the 2-position and a trifluoromethyl group at the 5-position. This chemical is used as a building block in pharmaceutical and agrochemical synthesis, as well as in the production of specialty chemicals. It is also used as a reagent in organic synthesis and as a solvent in chemical reactions. Additionally, it has applications in the manufacturing of dyes, pigments, and other industrial chemicals. Its unique structure and properties make it valuable in various chemical processes.

InChI:InChI=1/C12H8F3N/c13-12(14,15)10-6-7-11(16-8-10)9-4-2-1-3-5-9/h1-8H

Upstream product

• 143-66-8 sodium tetraphenyl borate 
• 50488-42-1 2-bromo-5-(trifluoromethyl)pyridine 
• 1078-58-6 diphenylzinc 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 100-58-3 phenylmagnesium bromide 
• 591-50-4 iodobenzene 
• 178204-50-7 2-(methylsulfonyl)-5-(trifluoromethyl)pyridine 
• 650592-47-5 2-(methylthio)-5-(trifluoromethyl)pyridine 
• 98-80-6 phenylboronic acid 
• 100-59-4 phenylmagnesium chloride 
• 108-86-1 bromobenzene 
• 1310559-91-1 2-trifluoromethylsulfonate-5-trifluoromethylpyridine 
• 603-33-8 triphenylbismuthane 

Downstream Products

• 27012-22-2 5-methyl-2-phenylpyridine 
• 936707-86-7 [Pt(C₆H₃Me₂-3,5)2(2-phenyl-5-(trifluoromethyl)pyridine)(dmso)] 
• 936707-87-8 [Pt(C₆H₃Me₂-3,5)(2-phenyl-5-(trifluoromethyl)pyridine^(1-)(dmso)] 

Relevant articles and documents

Luminescence properties of cyclometalated platinum(II) complexes in a dichloromethane/n-hexane system

The luminescence properties of three neutral cyclometalated Pt(II) complexes were investigated in a CH2Cl2/n-hexane system. The diphenylamino and trifluoromethyl modified Pt2 exhibits aggregation-induced phosphorescent emission (AIPE

Synthesis, characterization, and electroluminescent properties of iridium(III) 2-phenylpyridine-type complexes containing trifluoromethyl substituents and various main-group moieties

New heteroleptic cyclometalated iridium(III) 2-phenylpyridine-type complexes with trifluoromethyl substituents and various main-group moieties were synthesized and their photophysical, electrochemical, and electroluminescent (EL) properties studied. The emission color can be tuned by a facile derivatization of the phenyl moiety of 2-phenylpyridine with various main-group moieties, and we have prepared new yellowish-green to orange triplet emitters with enhanced charge injection/charge transporting features, which can furnish attractive EL performance in phosphorescent organic light-emitting devices (OLEDs). Attempts were also made to fabricate two-color white-light OLEDs based on a combination of fluorescent blue and phosphorescent orange emitters.

Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions

Heteroaromatic sulfinates are effective nucleophilic reagents in Pd0-catalyzed cross-coupling reactions with aryl halides. However, metal sulfinate salts can be challenging to purify, solubilize in reaction media, and are not tolerant to multi-step transformations. Here we introduce base-activated, latent sulfinate reagents: β-nitrile and β-ester sulfones. We show that under the cross-coupling conditions, these species generate the sulfinate salt in situ, which then undergo efficient palladium-catalyzed desulfinative cross-coupling with (hetero)aryl bromides to deliver a broad range of biaryls. These latent sulfinate reagents have proven to be stable through multi-step substrate elaboration, and amenable to scale-up.

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions

A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.