178242-60-9

Usage

Uses

Used in Pharmaceutical Industry:
α-Aminocyclohexylacetamide is used as a building block for the synthesis of various organic compounds and drug intermediates, contributing to the development of new medications.
Used in Medicinal Chemistry Research:
α-aminocyclohexylacetamide is utilized as a research tool to study its interactions with biological systems and its potential as a substrate for enzyme-catalyzed reactions, which could lead to the discovery of novel therapeutic agents.
Used in Antimicrobial Applications:
α-Aminocyclohexylacetamide has shown promise as a novel therapeutic agent with antimicrobial properties, indicating its potential use in combating bacterial infections.
Used in Antifungal Applications:
Similarly, the compound has demonstrated antifungal properties, suggesting its potential application in treating fungal infections and further research is needed to explore its full therapeutic potential in medicine and related fields.

Upstream product

• 67-56-1 methanol 
• 1552-92-7 ethyl cyclohexylideneacetate 
• 24571-98-0 1-aza-spiro[3.5]nonan-2-one 
• 5292-21-7 Cyclohexylacetic acid 

Downstream Products

• 178242-61-0 2-(1-dimethylamino-1-cyclohexyl)acetamide 

Relevant academic research and scientific papers

Novel 5-hydroxytryptamine 4 (5-HT4) receptor agonists. Synthesis and gastroprokinetic activity of 4-amino-N-[2-(1-aminocycloalkan-1-yl)ethyl]-5- chloro-2-methoxybenzamides

A novel series of 4-amino-N-[2-(1-aminocycloalkan-1-yl)ethyl]-5-chloro- 2-methoxybenzamide derivatives (1), which had amines conformationally restricted due to the effect of repulsion by neighboring substituents, were prepared and evaluated for 5-hydroxytryptamine 4 (5-HT4) agonistic activities by using the contraction of longitudinal muscle myenteric plexus (LMMP) of guinea pig ileum. One of the most potent compounds in this series was 4-amino-5-chloro-N-[2-(1-dimethylamino-1-cyclohexyl)ethyl]-2- methoxybenzamide (1c, YM-47813) with an EC50 value of 1.0 μM on LMMP. This compound effectively enhanced gastric motility and gastric emptying in conscious dogs by oral administration (1-3 mg/kg).

Synthesis of novel restricted diamines; 2-(1-aminocycloalkan-1- yl)ethylamines

Novel restricted diamines, 2-(1-aminocycloalkan-1-yl)ethylamines 1,were prepared by using Michael addition of ethyl cyclohexylideneacetate 2 and cycloalkylideneacetonitriles 7 with amines. In Michael addition, ester 2 needed high reaction temperature and gave several products, whereas 7 reacted smoothly and gave 2-(1-amino-1-cyclohexyl)acetonitriles 8 in good yield (NH3 85%, MeNH2 89%, EtNH2 80%) and were easily convened to diamines 1.

2,3-Diphenyl-5-ethylpyrazine

The compound 2,3-diphenyl-5-ethyl-pyrazine, useful as a precursor in the synthesis of those compounds of the class of pyrazine, arylpyrazine, diphenylpyrazine, and cycloalkylpyrazine malonates, acetates, acetamides, and acetic acids, useful for their ultraviolet light absorption properties.