178242-64-3

Basic information

• Product Name: (1-AMINO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER
• Synonyms: methyl (1-aminocyclohexyl)acetate;Methyl 2-(1-aMinocyclohexyl)acetate;Cyclohexaneacetic acid, 1-amino-, methyl ester
• CAS NO: 178242-64-3
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.13
• Mol File: 178242-64-3.mol

Chemical Properties

• Boiling Point: 228.877 °C at 760 mmHg
• Flash Point: 95.994 °C
• Appearance: /
• Density: 1.007 g/cm³
• Vapor Pressure: 0.072mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (1-AMINO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (1-AMINO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER(178242-64-3)
• EPA Substance Registry System: (1-AMINO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER(178242-64-3)

Safety Data

• Hazardous Substances Data: 178242-64-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1-Amino-cyclohexyl)-acetic acid methyl ester is used as a building block for the synthesis of various drugs, including analgesics and anti-inflammatory agents, due to its unique chemical structure that facilitates the development of therapeutically relevant compounds.
Used in Organic Synthesis:
(1-Amino-cyclohexyl)-acetic acid methyl ester is used as a key intermediate in organic synthesis for the creation of a range of organic compounds, leveraging its reactive functional groups to form diverse chemical entities.
Used in Chemical Research:
(1-Amino-cyclohexyl)-acetic acid methyl ester serves as a subject of chemical research to explore its reactivity, potential reactions, and applications in the development of new chemical methodologies and processes.
Used in Material Science:
(1-Amino-cyclohexyl)-acetic acid methyl ester may be utilized in material science for the development of new materials, potentially owing to its structural features that could influence material properties such as solubility, stability, or reactivity.

InChI:InChI=1/C9H17NO2/c1-12-8(11)7-9(10)5-3-2-4-6-9/h2-7,10H2,1H3

Upstream product

• 67-56-1 methanol 
• 1552-92-7 ethyl cyclohexylideneacetate 
• 37631-92-8 cis-amino-cyclohexaneacetic acid 
• 1192-37-6 methylenecyclohexane 
• 108-94-1 cyclohexanone 
• 24571-98-0 1-aza-spiro[3.5]nonan-2-one 
• 40203-74-5 methyl 2-cyclohexylideneacetate 

Downstream Products

• 1090903-26-6 {1-[3-(1,4-dimethyl-3H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-cyclohexyl}-acetic acid methyl ester 
• 1090900-28-9 {1-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-cyclohexyl}-acetic acid 
• 1090903-25-5 [1-(2-oxo-2,3-dihydro-benzimidazol-1-yl)-cyclohexyl]-acetic acid methyl ester 
• 1090903-24-4 [1-(2-amino-phenylamino)-cyclohexyl]-acetic acid methyl ester 
• 1090903-23-3 [1-(2-nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester 
• 178243-14-6 2-(1-pyrrolidinyl-1-cyclohexyl)ethylamine 
• 887472-15-3 {1-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-cyclohexyl}-acetic acid methyl ester 
• 212577-99-6 methyl 2-(1-dimethylamino-1-cyclohexyl)acetate 

Relevant articles and documents

CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS

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Synthesis and structure-activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors

A novel series of achiral TNF-α converting enzyme (TACE) inhibitors has been discovered. These compounds exhibited activities from 0.35 to 11 nM in a porcine TACE assay and inhibited TNF-α production in an LPS-stimulated whole blood assay with an IC5

Novel 5-hydroxytryptamine 4 (5-HT4) receptor agonists. Synthesis and gastroprokinetic activity of 4-amino-N-[2-(1-aminocycloalkan-1-yl)ethyl]-5- chloro-2-methoxybenzamides

A novel series of 4-amino-N-[2-(1-aminocycloalkan-1-yl)ethyl]-5-chloro- 2-methoxybenzamide derivatives (1), which had amines conformationally restricted due to the effect of repulsion by neighboring substituents, were prepared and evaluated for 5-hydroxytryptamine 4 (5-HT4) agonistic activities by using the contraction of longitudinal muscle myenteric plexus (LMMP) of guinea pig ileum. One of the most potent compounds in this series was 4-amino-5-chloro-N-[2-(1-dimethylamino-1-cyclohexyl)ethyl]-2- methoxybenzamide (1c, YM-47813) with an EC50 value of 1.0 μM on LMMP. This compound effectively enhanced gastric motility and gastric emptying in conscious dogs by oral administration (1-3 mg/kg).

Synthesis of novel restricted diamines; 2-(1-aminocycloalkan-1- yl)ethylamines

Novel restricted diamines, 2-(1-aminocycloalkan-1-yl)ethylamines 1,were prepared by using Michael addition of ethyl cyclohexylideneacetate 2 and cycloalkylideneacetonitriles 7 with amines. In Michael addition, ester 2 needed high reaction temperature and gave several products, whereas 7 reacted smoothly and gave 2-(1-amino-1-cyclohexyl)acetonitriles 8 in good yield (NH3 85%, MeNH2 89%, EtNH2 80%) and were easily convened to diamines 1.