178242-64-3

Basic information

• Product Name: (1-AMINO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER
• Synonyms: methyl (1-aminocyclohexyl)acetate;Methyl 2-(1-aMinocyclohexyl)acetate;Cyclohexaneacetic acid, 1-amino-, methyl ester
• CAS NO: 178242-64-3
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.13
• Mol File: 178242-64-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 228.877 °C at 760 mmHg
• Flash Point: 95.994 °C
• Appearance: /
• Density: 1.007 g/cm³
• Vapor Pressure: 0.072mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (1-AMINO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (1-AMINO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER(178242-64-3)
• EPA Substance Registry System: (1-AMINO-CYCLOHEXYL)-ACETIC ACID METHYL ESTER(178242-64-3)

Safety Data

• Hazardous Substances Data: 178242-64-3(Hazardous Substances Data)

Usage

General Description

(1-Amino-cyclohexyl)-acetic acid methyl ester is a chemical compound with the molecular formula C9H17NO2. It is a methyl ester derivative of (1-Amino-cyclohexyl)-acetic acid, which is an important intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical is used in the pharmaceutical industry as a building block for the synthesis of various drugs, including analgesics and anti-inflammatory agents. Its structure contains a cyclohexyl ring and an amino group, which give it important chemical properties for use in drug design and development. Additionally, (1-Amino-cyclohexyl)-acetic acid methyl ester may also have potential applications in other areas such as organic synthesis, chemical research, and material science.

InChI:InChI=1/C9H17NO2/c1-12-8(11)7-9(10)5-3-2-4-6-9/h2-7,10H2,1H3

Upstream product

• 67-56-1 methanol 
• 24571-98-0 1-aza-spiro[3.5]nonan-2-one 
• 37631-92-8 cis-amino-cyclohexaneacetic acid 
• 108-94-1 cyclohexanone 
• 40203-74-5 methyl 2-cyclohexylideneacetate 
• 1552-92-7 ethyl cyclohexylideneacetate 
• 1192-37-6 methylenecyclohexane 

Downstream Products

• 1090903-23-3 [1-(2-nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester 
• 178243-14-6 2-(1-pyrrolidinyl-1-cyclohexyl)ethylamine 
• 887472-15-3 {1-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-cyclohexyl}-acetic acid methyl ester 
• 212577-99-6 methyl 2-(1-dimethylamino-1-cyclohexyl)acetate 
• 1090903-26-6 {1-[3-(1,4-dimethyl-3H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-cyclohexyl}-acetic acid methyl ester 
• 1090900-28-9 {1-[3-(1,4-dimethyl-1H-indol-3-ylmethyl)-2-oxo-2,3-dihydro-benzimidazol-1-yl]-cyclohexyl}-acetic acid 
• 1090903-25-5 [1-(2-oxo-2,3-dihydro-benzimidazol-1-yl)-cyclohexyl]-acetic acid methyl ester 
• 1090903-24-4 [1-(2-amino-phenylamino)-cyclohexyl]-acetic acid methyl ester 

Relevant articles and documents

CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS

This invention is in the area of cell cycle inhibiting compounds for the treatment of disorders involving abnormal cellular proliferation, and include selective CDK2 inhibitors for medical therapy and their pharmaceutically acceptable salts and compositions.

Synthesis of novel restricted diamines; 2-(1-aminocycloalkan-1- yl)ethylamines

Novel restricted diamines, 2-(1-aminocycloalkan-1-yl)ethylamines 1,were prepared by using Michael addition of ethyl cyclohexylideneacetate 2 and cycloalkylideneacetonitriles 7 with amines. In Michael addition, ester 2 needed high reaction temperature and gave several products, whereas 7 reacted smoothly and gave 2-(1-amino-1-cyclohexyl)acetonitriles 8 in good yield (NH3 85%, MeNH2 89%, EtNH2 80%) and were easily convened to diamines 1.