178261-43-3

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 17996-12-2 N-benzyloxycarbonyl-6-amino-1-hexanol 
• 184241-22-3 1-O-4,4'-dimethoxytrityl-6-(N-phthaloylamino)-1-hexanol 
• 2009-83-8 6-chloro-1-hexanol 
• 63945-11-9 6-phthalimido-1-hexanol 
• 4048-33-3 6-amino-1-hexanol 

Downstream Products

• 184241-42-7 4-(2-{6-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyloxy}-ethyl)-3-nitro-benzoic acid methyl ester 
• 794520-41-5 C₃₂H₃₈N₂O₅ 
• 1204478-32-9 2-N-[6-O-(4,4'-dimethoxytrityl)hexyl]anthracene-2-carboxamide-9,10-dione-7-carboxylic acid 
• 669073-07-8 succinic acid mono-(2-{6-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-hexylcarbamoyl}-4-nitro-benzyl) ester 

Relevant academic research and scientific papers

3D small-molecule microarrays

A PEG based 3D hydrogel slide was developed specifically for small-molecule microarraying purposes, which displayed improved loading capacity, signal sensitivity and spot morphology compared with a commercially available slide and comparative 2D slide. The Royal Society of Chemistry 2009.

DUPLEX STABILIZING FLUORESCENCE QUENCHERS FOR NUCLEIC ACID PROBES

Diaryl-azo derivatives are efficient fluorescence quenchers as well as nucleic acid duplex-stabilizing agents and are useful in oligonucleotide conjugates and probes. The oligonucleotide-quencher conjugates may be used in detection methods for nucleic acid targets.

ENDOSOMAL CLEAVABLE LINKERS

The present disclosure relates generally to cleavable linkers and uses thereof.

MULTI-TARGETED SINGLE ENTITY CONJUGATES

The present invention relates, in general to, compounds, compositions and methods useful for modulating gene expression of multiple target nucleic acids by a single chemical entity.

New carbamate supports for the preparation of 3'-amino-modified oligonucleotides

A novel approach for the preparation of oligonucleotides carrying amino groups at the 3'-end is described. Several CPG supports having aminoalkyl groups and 3'-amino-2',3'-dideoxynucleosides linked through base-labile carbamate linkages such as 2-(2- nitrophenyl)ethoxycarbonyl and fluorenylmethoxycarbonyl were prepared using two different strategies. These supports are compatible to the standard solid phase phosphite-triester methodology and yield oligonucleotides containing amino groups at the 3'-end. Several properties of the 3'-amino oligonucleotides, such as nuclease resistance, hybridization, and preparation of oligonucleotide conjugates are discussed.