669073-07-8Relevant academic research and scientific papers
A novel solid support for the synthesis of 3′-aminoalkylated oligonucleotides
Leuck, Michael,Giare, Rubina,Paul, Matthias,Zien, Nicole,Wolter, Andreas
, p. 317 - 320 (2007/10/03)
A novel improved controlled pore glass (CPG) support based on the 2-(hydroxymethyl)-6-nitrobenzoyl (HMNB) protecting group was developed for the synthesis of 3′-aminoalkylated oligonucleotides. The release of oligonucleotides with free 3′-amino groups from the support is complete within 2h at 55°C in concentrated ammonia.
