1783-84-2Relevant academic research and scientific papers
PROCESS FOR PREPARING AND PURIFYING FATTY ACIDS
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, (2011/08/21)
There is provided a process for purifying a fatty acid, which process comprises reacting a fatty acid with a lithium salt in a first solution and under conditions to allow formation of a precipitate of a lithium salt of the fatty acid; isolating the precipitate; dissolving the precipitate in a second solution followed by separation of the organic and aqueous layers so formed; and evaporating the organic layer to isolate the purified fatty acid. There is also provided a process for increasing the length of a fatty acid, and the use of a lithium salt to purify a fatty acid.
Optimization of synthetic conditions for the preparation of dihomo-γ-linolenic acid from γ-linolenic acid
Xue, Gang,Liu, Fengxia,Wang, Ying,Huang, Kaixun
experimental part, p. 77 - 82 (2010/03/31)
Orthogonal experiments were employed to optimize the correlated parameters of reduction, sulfonation, substitution and hydrolysis. These reactions were used to convert γ-linolenic acids into dihomo-γ-linolenic acids (DGLA). For the reduction, the best rea
Delta6-desaturase genes and uses thereof
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, (2008/06/13)
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 6 (i.e., “Δ6-desaturase”). In particular, Δ6-desaturase may be utilized, for example, in the conversion of linoleic acid to γ-linolenic acid and in the conversion of α-linolenic acid stearidonic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
Desaturase genes and uses thereof
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, (2008/06/13)
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to γ-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
Desaturase genes and uses thereof
-
, (2008/06/13)
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to γ-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
A novel synthesis of (8Z,11Z,14Z)-8,11,14-eicosatrienoic (dihomo-γ-linoleic) acid and its 19-substituted analogue
Groza,Ivanov,Myagkova
, p. 401 - 404 (2007/10/03)
The total synthesis of dihomo-γ-linoleic acid and (8Z,11Z,14Z)-19-methyl-8,11,14-eicosatrienoic acid was accomplished using organometallic complexes of copper (I) in the cross-coupling reaction of propargyl synthones with terminal acetylenic reagents.
Chain extension with tert-butyl lithioacetate
Bos, Wil,Pabon, Henk J. J.
, p. 141 - 142 (2007/10/02)
Iodides containing methylene-interrupted triple or double bonds can be chain-extended in 45-73percent yield by reaction with tert-butyl lithioacetate in THF/HMPT at -35 deg C and subsequent acid-catalyzed thermolysis at 100 deg C.Alkyl and allyl bromides or iodides give acids in yields of 60 to 89percent.In some cases, minor amounts of methyl ketones were found.Alkyl chlorides and alkyl methane-, benzene- or p-toluenesulphonates are not suitable.
