178308-61-7

Basic information

• Product Name: 1,4-dichlorophthalazine-6-carbonitrile
• Synonyms: 1,4-dichlorophthalazine-6-carbonitrile;1,4-Dichloro-6-phthalazinecarbonitrile
• CAS NO: 178308-61-7
• Molecular Formula: C₉H₃Cl₂N₃
• Molecular Weight: 224.04622
• Mol File: 178308-61-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.57
• CAS DataBase Reference: 1,4-dichlorophthalazine-6-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dichlorophthalazine-6-carbonitrile(178308-61-7)
• EPA Substance Registry System: 1,4-dichlorophthalazine-6-carbonitrile(178308-61-7)

Safety Data

• Hazardous Substances Data: 178308-61-7(Hazardous Substances Data)

Usage

General Description

1,4-dichlorophthalazine-6-carbonitrile is a chemical compound that belongs to the group of phthalazine derivatives. It is a white solid with the molecular formula C8H2Cl2N2 and a molecular weight of 204.02 g/mol. 1,4-dichlorophthalazine-6-carbonitrile has been studied for its potential applications in the pharmaceutical industry, particularly in the development of new drugs. It possesses interesting biological activities, including antimicrobial and antiparasitic properties, and may have potential as a lead compound for the development of novel therapeutics. Additionally, 1,4-dichlorophthalazine-6-carbonitrile has been investigated for its potential use as an intermediate in the synthesis of other organic compounds. Overall, this chemical compound has garnered attention for its potential pharmaceutical and industrial applications.

Upstream product

• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 178309-35-8 6-cyano-2,3-dihydro-1,4-phthalazinedione 
• 1204-28-0 trimellitic anhydride acid chloride 
• 21343-93-1 trimellitic acid amide-imide 
• 34613-09-7 1,3-dioxoisoindoline-5-carbonitrile 
• 3676-85-5 4-aminophthalimide 
• 178309-36-9 6-carbamoyl-2,3-dihydro-1,4-phthalazinedione 

Downstream Products

• 178308-63-9 1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine 
• 240400-76-4 1-chloro-4-[(3-cyano-4-methoxybenzyl)amino]-6-phthalazine carbonitrile 
• 1095639-29-4 (R)-(4-(4-chloro-6-cyanophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone 
• 1095639-27-2 (R)-(4-(4-chloro-7-cyanophthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone 

Relevant articles and documents

Remedy for erection failure comprising fused pyridazine compound

The present invnetion provides a remedy for erectile dysfunction. The active ingredient thereof is a fused pyridazine compound represented by the following formula (I) or a pharmacologically acceptable salt thereof: (wherein the ring C represents a 5 or 6

4-Benzylamino-1-chloro-6-substituted phthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5

We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted phthalazines (16) and evaluated their inhibitory activity toward phosphodiesterase 5 (PDE5) purified from porcine platelets. The PDE5-inhibitory activities of 15 were greater than those of the isomers (16). The preferred substituent at the 4-position of phthalazine was a (3-chloro-4-methoxybenzyl)amino group, and those at the 6- position were cyano, nitro, and trifluoromethyl groups. Compounds 15a (IC50 = 4.8 nM), 15f (3.5 nM), and 15i (5.3 nM) were more potent inhibitors than E4021 (8.6 nM). Compounds 15a and 15f also showed vasorelaxant activity in isolated porcine coronary arteries precontracted with prostaglandin F(2α) (10-5 M). The EC50 values for vasorelaxant action of 15a, 15f, and E4021 were 150, 160, and 980 nM, respectively. These results show that novel PDE5 inhibitors possessing a potent vasorelaxant effect may exist among phthalazine derivatives.