178484-49-6

Upstream product

• 147118-02-3 diphenylmethyl (4R,5R,6S)-3-diphenylphosphoryloxy-6-<(1R)-1-hydroxyethyl>-4-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-en-2-carboxylate 
• 178484-46-3 C₁₆H₃₁N₃O₆S₂ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 148017-07-6 (2S,4R)-N-tetr-butoxycarbonyl-4-methanesulfonyloxy-2-hydroxymethylpyrrolidine 
• 148017-42-9 (2S,4S)-4-acetylthio-1-t-butoxycarbonylpyrrolidine-2-methanol 
• 1054609-78-7 C₁₈H₃₃N₃O₇S₂ 
• 125987-94-2 N-(tert-butoxycarbonyl)-N'-(methyl)sulfamide 

Relevant academic research and scientific papers

Synthesis and modification of a novel 1 β-methyl carbapenem antibiotic, S-4661

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.