125987-94-2

Basic information

• Product Name: tert-Butyl N-(methylsulfamoyl)carbamate
• Synonyms: Carbamic acid, [(methylamino)sulfonyl]-,1,1-dimethylethyl ester;[(Methylamino)sulfonyl]carbamic acid 1,1-dimethylethyl ester;tert-Butyl N-(methylsulfamoyl)carbamate;Carbamic acid, [(methylamino)sulfonyl]-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 125987-94-2
• Molecular Formula: C6H14N2O4S
• Molecular Weight: 210.25
• Product Categories: N-BOC
• Mol File: 125987-94-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.238g/cm³
• Refractive Index: 1.475
• CAS DataBase Reference: tert-Butyl N-(methylsulfamoyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl N-(methylsulfamoyl)carbamate(125987-94-2)
• EPA Substance Registry System: tert-Butyl N-(methylsulfamoyl)carbamate(125987-94-2)

Safety Data

• Hazardous Substances Data: 125987-94-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H14N2O4S/c1-6(2,3)12-5(9)8-13(10,11)7-4/h7H,1-4H3,(H,8,9)

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 75-65-0 tert-butyl alcohol 
• 147000-89-3 N-tert-butyloxycarbonylsulfamoyl chloride 
• 74-89-5 methylamine 

Downstream Products

• 72179-84-1 N-methylsulfamide 
• 178484-49-6 C₃₉H₅₂N₄O₁₀S₂ 

Relevant articles and documents

Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits.

There is a need for fast detection methods for the banned rodenticide tetramethylenedisulfotetramine (TETS), a highly potent blocker of the γ-aminobutyric acid (GABAA) receptors. General synthetic approach toward two groups of analogues was dev

N-(Alkylsulfamoyl)aldimines: Easily deprotected precursors for diarylmethylamine synthesis

The sequential reaction of chlorosulfonyl isocyanate with t-BuOH, t-BuNH2 and TFA allows formation of H2NSO 2NHBut. Condensation of the latter with Ar1CHO in the presence of Ti(OEt)4 provides the activated imines Ar 1CHNSO2NHBut (59-89%). Commercially available boronic acids add to these imines with good stereoselectivity (76-98% ee) using readily available diene ligands. Simple deprotection with 5% w/w water in pyridine affords free Ar1CHNH2Ar2.

Synthesis and modification of a novel 1 β-methyl carbapenem antibiotic, S-4661

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.