125987-94-2Relevant academic research and scientific papers
Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits.
Barnych, Bogdan,Vasylieva, Natalia,Joseph, Tom,Hulsizer, Susan,Nguyen, Hai M.,Cajka, Tomas,Pessah, Isaac,Wulff, Heike,Gee, Shirley J.,Hammock, Bruce D.
, p. 8466 - 8472 (2017)
There is a need for fast detection methods for the banned rodenticide tetramethylenedisulfotetramine (TETS), a highly potent blocker of the γ-aminobutyric acid (GABAA) receptors. General synthetic approach toward two groups of analogues was dev
DOUBLE-HEADED PROTEASE INHIBITOR
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Paragraph 1092; 1093; 1095, (2020/09/17)
The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compo
N-(Alkylsulfamoyl)aldimines: Easily deprotected precursors for diarylmethylamine synthesis
Crampton, Rosemary H.,Fox, Martin,Woodward, Simon
, p. 599 - 605 (2013/06/27)
The sequential reaction of chlorosulfonyl isocyanate with t-BuOH, t-BuNH2 and TFA allows formation of H2NSO 2NHBut. Condensation of the latter with Ar1CHO in the presence of Ti(OEt)4 provides the activated imines Ar 1CHNSO2NHBut (59-89%). Commercially available boronic acids add to these imines with good stereoselectivity (76-98% ee) using readily available diene ligands. Simple deprotection with 5% w/w water in pyridine affords free Ar1CHNH2Ar2.
One-pot synthesis of N-acyl-substituted sulfamides from chlorosulfonyl isocyanate via the Burgess-type intermediates
Masui, Yoshiyuki,Watanabe, Hideaki,Masui, Toshiaki
, p. 1853 - 1856 (2007/10/03)
The title N-alkoxycarbonyl- or N-aryloxycarbonyl-substituted sulfamides were synthesised in one-pot in efficient yields from chlorosulfonyl isocyanate (CSI), alcohols and aqueous (or dry) amines via the corresponding water-resistant intermediates, carboxy
Synthesis and modification of a novel 1 β-methyl carbapenem antibiotic, S-4661
Iso,Irie,Iwaki,Kii,Sendo,Motokawa,Nishitani
, p. 478 - 484 (2007/10/03)
We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.
